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MORTALITY BREEDS COMPLEXITY. "We take note of the fact that mortal organisms endowed with programmed self-decomposition are more complex than immortal organisms in both structural and functional aspects, and that the former can better increase the prosperity of their offspring than the latter can." http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.657.723&rep=rep1&type=pdf View in LinkedIn

EYE OF NEWT AND TOE OF FROG. "By sequencing full genomes from purified bacteriophage WO particles of Wolbachia, we discover a novel eukaryotic association module with various animal proteins domains, such as the black widow latrotoxin-CTD, that are uninterrupted in intact bacteriophage genomes, enriched with eukaryotic protease cleavage sites, and combined with additional domains to forge some of the largest bacteriophage genes (up to 14,256 bp)." (Macbeth Act IV Scene I). https://lnkd.in/dYh3-r4 View in LinkedIn

MORTALS, IMMORTALS AND MUTANTS. "Our findings suggest that, in the case of a mortal organism appearing among a population of immortal organisms as a mutant which evolutionarily acquires a genetic program for death by means of self-decomposition, this organism and its surviving offspring surpass immortal organisms and eventually prosper with adaptive divergence under various environmental conditions within a certain probability." http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.657.723&rep=rep1&type=pdf View in LinkedIn

MODEL OF AUTONOMOUS DEATH. "We formed the hypothesis that originally immortal terrestrial organisms evolve into ones that are programmed for autonomous death. We then conducted simulation experiments in which we examined this hypothesis using an artificial ecosystem that we designed to refer to a terrestrial ecosystem endowed with Artificial Chemistry." https://lnkd.in/dtsPf9E View in LinkedIn

MISSING REFERENCE FOR TODAY. " "Are Internal, Death-Promoting Mechanisms Ever Adaptive?" "John W Pepper, Deborah E Shelton, Armin Rashidi and Pierre M Durand View in LinkedIn

DEATH MACHINERY IS CONSERVED. "The machinery of apoptosis is well conserved among animals and it is composed of caspases (the proteases which execute cell death), adapter proteins (caspase activators), Bcl‐2 family proteins and Inhibitor of Apoptosis Proteins (IAPs)." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

CELL DEATH BY "Apoptosis occurs in animals as a consequence of a variety of stimuli including stress and social signals and it plays essential roles in morphogenesis and immune defense." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

LIFE CYCLES. "Programmed Cell Death is essential for the life cycle of many organisms." https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

TISSUE ENGINEERING. "Classical examples of this are the removal of the tadpole’s tail of frogs during metamorphosis or the disappearance of interdigital tissues during mammalian development to sculpt fingers. In the adult animal, unwanted cells are eliminated through PCD when they are no longer needed." (PCD = programmed cell death). https://celldeath.files.wordpress.com/2010/11/lopezself_munoz.pdf View in LinkedIn

BIRTH BALANCES DEATH. "Every second, several millions of cells of the human body undergo apoptosis, i.e. in conditions of homeostasis each mitosis is compensated by one event of apoptosis." http://mcb.berkeley.edu/courses/mcbc245/MCBC245PDFs/Jan31/Huettenbrenner2003.pdf View in LinkedIn