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"A PARADIGM SHIFT: programmed cell death and apoptosis in single-celled organisms. Programmed cell death in four diverging phylogenic branches of single-celled eukaryotes." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

NO BRIGHT LINE. "Interestingly some unicellular protozoans have developed a primitive form of non-necrotic cell death themselves, which could mean that the idea of an altruistic death for the benefit of genetically identical cells predated the invention of multicellularity." http://mcb.berkeley.edu/courses/mcbc245/MCBC245PDFs/Jan31/Huettenbrenner2003.pdf View in LinkedIn

UNICELLULAR programmed cell death and relatives could be the same as organismal death, but many authors thought that this idea did not pass the sniff test. However, surprising new findings have colored this discussion. http://mcb.berkeley.edu/courses/mcbc245/MCBC245PDFs/Jan31/Huettenbrenner2003.pdf View in LinkedIn

BIM-BAD-AND-BAX, ET AL. "Many regulators of apoptosis are located in the mitochondrion or in the mitochondrial inter-membrane space (caspases 2, 3, and 9, cytochrome c, Bcl-2, Bcl-XL, Bad, Bax, Bak, Bim, Smac, HtrA2, AIF). However, we do not find these or homologous components (except HtrA) in contemporary bacteria." http://mcb.berkeley.edu/courses/mcbc245/MCBC245PDFs/Jan31/Huettenbrenner2003.pdf View in LinkedIn

ADAPTED GENES. "Since evolution never invents new genes but plays variations on old themes by DNA mutations, it is not surprising, that some of the genes involved in metazoan death pathways apparently have evolved from homologues in unicellular organisms, where they originally had different functions." http://mcb.berkeley.edu/courses/mcbc245/MCBC245PDFs/Jan31/Huettenbrenner2003.pdf View in LinkedIn

GENOMIC STREAMLINING. "Genomic researchers have proposed that natural selection may favor small genomes—weeding out superfluous material—through a process called “genomic streamlining. Streamlining makes inherent sense because a small genome should aid metabolic efficiency, because genome size is correlated with cell size." http://scholar.google.es/scholar?q=selective+pressures+for+genomic+simplicity&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwi8_67jh8zPAhXBbRQKHa6-BbEQgQMICDAA View in LinkedIn

UNDER THE RADAR. "Natural selection can favor the propagation of given genes for the sole reason that they are successful at propagating themselves, while being of no advantage, or sometimes while even being detrimental, to the fitness of the organisms that carry them. Such genes have been called 'selfish genes." http://www.nature.com/cdd/journal/v9/n4/full/4400950a.html View in LinkedIn

MASSIVE GENE LOSS. "Two notable examples are the reconstruction of the complex archaeal ancestor and the intron-rich ancestor of eukaryotes. In both cases, evolution in most of the lineages was apparently dominated by extensive loss of genes and introns, respectively." http://onlinelibrary.wiley.com/doi/10.1002/bies.201300037/full View in LinkedIn

INFREQUENT EXAMPLES. "As logical as genomic streamlining might be, few examples have so far been found. Instead, a bevy of articles from the last 10 years show that three separate lines of evidence argue against widespread streamlining in prokaryotes." https://lnkd.in/d3Ys7Am View in LinkedIn

GENOME DOWNSIZING. "Evolutionary chromosome change involves significant variation in DNA amount in diploids and genome downsizing in polyploids." https://lnkd.in/dmkwGfy View in LinkedIn