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REDUCTIONISM. "During the latter half of the 20th century, biology was dominated by reductionist approaches that successfully generated information about individual cellular components and their functions. Over the past decade, this process has been greatly accelerated by the emergence of genomics." https://scholar.google.es/scholar?q=in+silico+chemistry+of+emergence+of+life&hl=en&as_sdt=0&as_vis=1&oi=scholart&sa=X&ved=0ahUKEwj40qHQlMXLAhWCnRoKHRtCAjkQgQMICDAA View in LinkedIn

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THE SECRET OF LIFE'S ORIGIN has been evasive. In part because it had eons in which to happen, under conditions we could hardly begin to replicate. Included in this question is the simple, yet heretical, question — did life only arise on Planet Earth? View in LinkedIn

Great initiative! https://www.theguardian.com/world/2018/dec/05/luxembourg-to-become-first-country-to-make-all-public-transport-free?CMP=Share_iOSApp_Other View in LinkedIn

LIFE ORIGINS. "According to their model, during the night cycles, multiple short polymers bond to longer polymer strands, which act as templates. These longer template strands hold the shorter polymers in close enough proximity to each other that they can ligate to form a longer strand -- a complementary copy of at least part of the template. Over time, the newly synthesized polymers come to dominate, giving rise to an autocatalytic and self-sustaining system of molecules large enough to potentially encode blueprints for life, the model predicts." https://publishing.aip.org/publishing/journal-highlights/origins-life-new-model-may-explain-emergence-self-replication-early View in LinkedIn

REPLICON PROOF. "My colleagues and I... have designed such self-assembling molecules and crafted them in the laboratory... Our organic molecules, although they operate outside of living systems, help to elucidate some of the essential principles of self-replication.'' https://lnkd.in/dn83zJW View in LinkedIn

REPLICON MODEL. "Imagine a molecule that likes its own shape: finding a copy of itself, it will fit neatly with its twin, forming for a while a complete entity. If the original molecule is presented with the component parts of itself, it will assemble these into additional replicas. The process will continue as long as the supply of components lasts." https://lnkd.in/dn83zJW View in LinkedIn

MOLECULAR REPLICATION. "We’ve published a body of work … where we’ve made small molecules that are capable of copying themselves...Just having a small molecule that replicates itself is not … ultimately very complex.’ https://lnkd.in/dDrKtFQ View in LinkedIn

"THE RNA WORLD HYPOTHESIS describes an early Earth with self-replicating and catalytic RNA but no DNA or proteins. It is generally accepted that current life on Earth descends from an RNA world, although RNA-based life may not have been the first life to exist." https://en.m.wikipedia.org/wiki/Abiogenesis View in LinkedIn

SUMMARY of self-replicating simple and complex molecules that make prions seem much more normal. Here are summaries of self-replicating systems including: hexadeoxynucleotides, RNA li gases, peptides, small molecules, ribozymes, micelles, prions and amyloid. https://lnkd.in/d6v_X9T View in LinkedIn