Category: Uncategorized

OUTPERFORMED. "We built and tested a detailed logical model (involving genes, proteins and metabolites) of the aromatic amino acid synthesis pathway. In biological experiments that automatically reconstruct parts of this model, we show that an intelligent experiment selection strategy is competitive with human performance and significantly outperforms, with a cost decrease of 3-fold and 100-fold (respectively), both cheapest and random-experiment selection." https://lnkd.in/d_c-WZa View in LinkedIn

DNA PUMPS. "Diverse bacteria and archaea are competent for natural transformation that is mediated by dedicated DNA intake pumps. These pumps can be legitimately considered devices for utilization of environmental DNA as a source of nucleotides (simply put, food), with HGT being a fringe benefit." (HGT = horizontal gene transfer). https://lnkd.in/dSemZpD View in LinkedIn

DERIVING GLYCOLYSIS. "The biological system that the researchers used to test ABE is glycolysis, the primary process that produces energy in a living cell. The ability to generate mathematical equations from scratch is what sets ABE apart from Adam, the robot scientist developed by Ross King and his colleagues at the University of Wales at Aberystwyth." https://lnkd.in/eGii4i4 View in LinkedIn

SEA OF DNA. "HGT might be considered a by-product of the presence of substantial amounts of DNA in the environment combined with genetic processes such as transformation and bacteriophage infection that leads to gene transduction." (HGT = horizontal gene transfer). https://lnkd.in/dSemZpD View in LinkedIn

MACHINE SCIENCE. "We have confirmed Adam’s conclusions through manual experiments. To describe Adam’s research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge." (Ross King). https://lnkd.in/dJJ9HmD View in LinkedIn

SCIENCE BY ROBOTS. "The scientists in Britain, led by Ross D. King, a professor at Aberystwyth University, built a robotic scientist they named Adam. Using artificial intelligence, it came up with a hypothesis about genes in baker’s yeast and the enzymes produced by the genes. It then designed and ran experiments to test its hypothesis. Using the results, it revised its hypothesis and ran more experiments before arriving at its conclusions." https://lnkd.in/djSTtXn View in LinkedIn

HISTORICAL FIRST. "While researching yeast-based functional genomics, Adam became the first machine in history to have discovered new scientific knowledge independently of its human creators." https://lnkd.in/dB_3QTR View in LinkedIn

ROBOTC SYSTEM. "We describe a physically implemented robotic system that applies techniques from artificial intelligence to carry out cycles of scientific experimentation. The system automatically originates hypotheses to explain observations, devises experiments to test these hypotheses, physically runs the experiments using a laboratory robot, interprets the results to falsify hypotheses inconsistent with the data, and then repeats the cycle." https://lnkd.in/d_c-WZa View in LinkedIn

ROBOT ADAM “is capable of: hypothesizing to explain observations; devising experiments to test these hypotheses; physically running the experiments using laboratory robotics; interpreting the results from the experiments; repeating the cycle as required." https://lnkd.in/dB_3QTR View in LinkedIn

ROBOT SCIENTIST ADAM. "The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist “Adam,” which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation." (Ross King). https://lnkd.in/dJJ9HmD View in LinkedIn