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CUE CANDIDATES. "These observations suggest the attractive possibility that the threshold for triggering a self-amplifying asymmetry is associated with the formation kinetics of local Rho-depleted and/or Par-2-rich/myosin inhibitory domains. Simple mathematical analyses show that such feedback loops could endow the cortex with a threshold response." https://lnkd.in/dAxynvD View in LinkedIn

SURPRISE FINDINGS. "Phylogenetic analyses of asymmetry variation, inheritance, and molecular mechanisms reveal unexpected insights into how development evolves." Especially applied to the symmetry of the heart. https://lnkd.in/dAEUFWY View in LinkedIn

CUE THRESHOLD. "There is a threshold level of inhibition that the cue must exceed to trigger symmetry breaking. This could either be a threshold in the inhibition domain size, the duration of inhibition, or both." https://lnkd.in/dAxynvD View in LinkedIn

LEFT-RIGHT ASYMMETRY. "Because of its simplicity, the binary-switch nature of left-right asymmetry permits meaningful comparisons among many different organisms." https://lnkd.in/dAEUFWY View in LinkedIn

CUES AND NO CUES. "Some symmetry-breaking systems require a polarizing cue. Others can spontaneously break symmetry in the absence of any cues, often by amplifying local stochastic fluctuations in the concentrations of participating molecules. In these cases, polarizing cues “choose” the axis of symmetry breaking." https://lnkd.in/dAxynvD View in LinkedIn

FRAGMENT FROM NATURE deals with symmetry and symmetry breaking in animal body design. Symmetry is a common theme that threads through biology, physics and chemistry. It seems fundamental to how the universe is configured. In biology, the issue of symmetry starts at the first cell division of the egg, and does not stop thereafter. It seems that symmetry breaking and chirality is embedded in the very geometry of shape. View in LinkedIn

CUE IDENTITIES. "The identity of the cue(s) that trigger polarization, and whether this cue involves microtubules, has been an ongoing controversy." https://lnkd.in/dAxynvD View in LinkedIn

INSCRUTABLE. "Self-modifying code is notoriously hard to understand and therefore very well suited to hide program internals. Self-modifying code has a long history of hiding the internals of a program. It was used to hide copy protection instructions in 1980s MS DOS based games." https://lnkd.in/dzxTmXb View in LinkedIn

DOWNSTREAM EFFECTS. "The asymmetrically localized Par proteins in turn shape the distributions of cytoplasmic factors that specify different developmental potentials. They also shape the distributions of cortical factors that position the mitotic spindle, and thus the first cleavage furrow, to segregate correctly developmental potentials to unequally sized daughters." https://lnkd.in/dAxynvD View in LinkedIn

THE SPERM CUE. "Acting on an essentially unpolarized cell, the sperm cue triggers a rapid reorganization of the cell cortex, accompanied by the de novo enrichment of conserved polarity determinants known as Par proteins within complementary anterior and posterior cortical domains." https://lnkd.in/dAxynvD View in LinkedIn