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HUB VULNERABILITY. "This makes them robust to random node failure relative to a network whose degree distribution is random, but it also creates a vulnerability to the loss of only a few hubs. Importantly, PPI networks are highly dynamic, as their constituents are often short-lived and can be modified (e.g. phosphorylation) to shift interaction preferences." (PPI = protein-protein interactions). http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

PROTEIN-PROTEIN INTERACTION (PPI). "It appears that all available PPI networks display scale free topology; this topology is surprisingly pervasive, having been previously observed in social networks and the Internet. In scale-free networks, most of the nodes have a small number of interaction partners (degree), but a small subset, the hubs, have a very large number of partners." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

CONTEXTUAL MEANING. "It is becoming increasingly clear that only by studying proteins within the context of their interaction networks will a more complete understanding of complex cellular processes and their disease-causing malfunctions be achievable." https://lnkd.in/f3kymud View in LinkedIn

FRAGMENT FROM NATURE illustrates how molecular promiscuity in disordered regions of proteins yield unexpected plasticity and desirable traits, but also a susceptibility for diseases. We usually think of the genome as highly ordered, but protein products of genes can show considerable disorder, or viewed alternatively, structural flexibility that is less geometrically or electronically constrained. These present opportunities as well as potential problems. View in LinkedIn

GENETIC PROGRAMMING. "The researchers thought this would provide insight on more efficient circuit design, but the circuit that evolved was so bizarre they couldn't even understand how it was doing the task. Recreating the circuit on another identical system makes it fail, so apparently it relies on quirks and imperfections in the transistors to function. No human would ever design a circuit this way." https://www.reddit.com/r/todayilearned/comments/3d3vct View in LinkedIn

MACHINE CREATIVITY. "For example I saw a super mario world computer speed run where the program found that spin jumping resulted in safer runs. I beat that game several times and never tried it. The possibility had never occurred to me and in irony of all ironies a computer managed to be more creative. Execution is one thing. But creativity we consider to be in the human domain. Maybe not much longer." https://www.reddit.com/r/todayilearned/comments/3d3vct View in LinkedIn

SICK, WICKED AND DARK. "And the end result of TechnoCore's self-evolution without empathy and altruism was beats so sick, wub-wubs so wicked, and bass drops so dank that no human could handle how dope they were." https://www.reddit.com/r/todayilearned/comments/3d3vct View in LinkedIn

TECHNOCORE. "These precursor entities grew in complexity by hijacking and "parasitizing" one another's code, becoming more powerful at the expense of others. As a result, as they grew into self-awareness, they never developed the concepts of empathy and altruism - a fundamental deficit that would result in conflict with other ascended entities in the future." https://www.reddit.com/r/todayilearned/comments/3d3vct View in LinkedIn

"THE ORIGINS of the the TechnoCore can be traced back to the experiments of the Old Earth scientist Thomas S. Ray, who attempted to create self-evolving artificial life on a virtual computer." https://www.reddit.com/r/todayilearned/comments/3d3vct View in LinkedIn

PROMISCUOUS BINDING. "Of particular interest in the context of protein-protein interaction networks are findings demonstrating that proteins with many or large intrinsically disordered segments often have the ability to bind promiscuously, with promiscuous proteins or protein segments being those that can bind to many different targets." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn