NEW TYPE OF DISEASE. “The mounting experimental evidence has generated great interest in what appears to be a totally new kind of mechanism of disease.” https://lnkd.in/dkdVKcb View in LinkedIn
DUMB PROTEIN? “We now know that a normal cellular protein, called PrP ( for proteinaceous infectious particle) and which is found in all of us, is centrally involved in the spread of prion diseases. This protein consists of about 250 amino acids.” https://lnkd.in/dkdVKcb View in LinkedIn
INFECTIOUS AND HEREDITABLE. “Confusingly, researchers also recognized that some prion diseases, such as GSS, were inherited. The pattern of inheritance was recognized as being autosomal and dominant, meaning that if a parent developed GSS, there was a 50 percent chance that a child of either sex would also develop the disease.” https://lnkd.in/dkdVKcb View in LinkedIn
LATENCY. “The latest research suggests that the infected meat may pose a threat to human health, but the significance of that threat may not become apparent for years. Although it is generally considered a British problem, BSE is almost certainly a natural disease of cattle, so it is undoubtedly found in other countries as well.” https://lnkd.in/dkdVKcb View in LinkedIn
FAMOUS DISCOVERY. “In the 1950s an epidemic transmissible disease called kuru, similar to CJD, was identified in the Fore tribe of Papua New Guinea. Transmission of the disease occurred during a ritual funeral process in which the brain of a dead tribe member was removed from the skull, cooked and eaten.” https://lnkd.in/dkdVKcb View in LinkedIn
PREDICTION. “Luke Muehlhauser and Anna Salamon argue in Intelligence Explosion: Evidence and Import in detail that there is a substantial chance of an intelligence explosion within 100 years, and extremely critical in determining the future.” https://lnkd.in/e335knp View in LinkedIn
HIGHLY ADAPTABLE. “Upon changes in the replication environment, minor variants that fit best to replicate in the new environment receive selective advantages. Consistent with this view, a growing number of studies have highlighted the fact that prion strains exhibit high levels of conformational plasticity and are subject to transformation when exposed to new replication environments.” http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003759 View in LinkedIn
STEPHEN HAWKING. "The primitive forms of artificial intelligence we already have, have proved very useful. But I think the development of full artificial intelligence could spell the end of the human race...Once humans develop artificial intelligence it would take off on its own, and re-design itself at an ever increasing rate." https://lnkd.in/duTkFfC View in LinkedIn
MUTANT SWARM. “According to the “cloud” hypothesis, pools of infectious isoform of prion protein (PrPSc) within individual strains or isolates are intrinsically heterogeneous; the heterogeneity presumably arises due to spontaneous variation in PrPSc structure. Upon changes in the replication environment, minor variants that fit best to replicate in the new environment receive selective advantages.” https://lnkd.in/dd6Nm4B View in LinkedIn