linkedin post 2019-12-14 06:24:17

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ONE MILLION PROTEINS, 21K GENES. "One gene can encode more than one protein (even up to 1,000). The human genome contains about 21,000 protein-encoding genes, but the total number of proteins in human cells is estimated to be between 250,000 to one million." No longer the one gene, one protein dogma. https://lnkd.in/dKXbSw4 View in LinkedIn
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linkedin post 2019-12-15 05:19:34

linkedin post 2019-12-15 05:19:34

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CRUCIAL ROLES. "Most human genes are alternatively spliced, allowing the selection of different combinations of exons to produce multiple distinct mRNAs and proteins. Many types of alternative splicing are known to play crucial roles in biological processes including cell fate determination, tumor metabolism, and apoptosis." http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001229 View in LinkedIn
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linkedin post 2019-12-15 05:15:18

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SPLICEOSOME. "Splicing is carried out by the spliceosome, a massive structure in which five small nuclear ribonucleoprotein particles (snRNPs) and a large number of auxiliary proteins cooperate to accurately recognize the splice sites and catalyse the two steps of the splicing reaction." https://lnkd.in/d5-PmqK View in LinkedIn
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linkedin post 2019-12-17 05:38:44

linkedin post 2019-12-17 05:38:44

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RETINAL HACK. “Optogenetics is also being considered for a new generation of sensory devices, like retinal implants to help people who have lost their vision regain some degree of sight. Today, the Argus II, a retinal implant made by Second Sight, works by transforming a camera feed into electrical impulses. These travel to an implant inside a person’s eye, where they stimulate surviving photoreceptors and pass visual information to the brain.” http://www.wsj.com/articles/a-bright-approach-to-brain-implants-1453480543 View in LinkedIn
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linkedin post 2019-12-17 05:36:24

linkedin post 2019-12-17 05:36:24

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HACKING BRAIN GENES. “One of the most promising tools in this regard is a recently developed technique called optogenetics, which hijacks the molecular machinery of the genes found inside every neuron to directly manipulate the brain's circuitry.” http://www.wsj.com/articles/SB10001424052702304914904579435592981780528 View in LinkedIn
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linkedin post 2019-12-15 05:11:59

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FOR BETTER AND FOR WORSE. "Alternative splicing of mRNA precursors provides an important means of genetic control and is a crucial step in the expression of most genes. Alternative splicing markedly affects human development, and its misregulation underlies many human diseases." https://lnkd.in/d5-PmqK View in LinkedIn
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