linkedin post 2020-01-16 08:23:44

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SEROTONIN. "Although commensal microbes can produce neuroactive molecules, recent work revealed a microbe–host mechanism of serotonin production. Spore-forming bacteria within the gut microbiota release metabolites, including SCFAs, signalling EC production of serotonin." http://onlinelibrary.wiley.com/doi/10.1111/cmi.12585/full View in LinkedIn
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linkedin post 2020-01-16 08:21:08

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SEROTONIN-BACTERIA INTERFACE. "The vast majority of serotonin, an estimated 95%, is found within the GI tract. Here, 90% of serotonin is localized within epithelial enterochromaffin cells (ECs) and the remaining 10% remains within the ENS. And while serotonin biosynthesis in the brain remains largely independent of the GI tract, serotonin biosynthesis within the GI tract involves specific microbiota–gut interactions." http://onlinelibrary.wiley.com/doi/10.1111/cmi.12585/full View in LinkedIn
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linkedin post 2020-01-15 05:00:37

linkedin post 2020-01-15 05:00:37

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"THE BRAIN-GUT AXIS is a bidirectional communication system between the central nervous system and the gastrointestinal tract. Serotonin functions as a key neurotransmitter at both terminals of this network. Accumulating evidence points to a critical role for the gut microbiome in regulating normal functioning of this axis." http://www.sciencedirect.com/science/article/pii/S0166432814004768 View in LinkedIn
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linkedin post 2020-01-15 04:58:20

linkedin post 2020-01-15 04:58:20

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BACTERIA-HUMAN COGNITION INTERFACE. "Given the relationship between serotonin, cognition and social responses and the impact of kynurenine pathway metabolites on cognitive performance and, the ability of the microbiota to influence these behavioural domains should perhaps not surprise us." http://www.sciencedirect.com/science/article/pii/S0166432814004768 View in LinkedIn
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linkedin post 2020-01-15 04:55:29

linkedin post 2020-01-15 04:55:29

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BACTERIA-MOUSE INTERFACE. "The influence of the gut microbiota on behaviour also extends to cognitive function and in the novel object recognition test and the T-maze germ-free mice exhibit non-spatial, hippocampal mediated, and working memory deficits." http://www.sciencedirect.com/science/article/pii/S0166432814004768 View in LinkedIn
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linkedin post 2020-01-15 04:52:11

linkedin post 2020-01-15 04:52:11

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BACTERIA-HUMAN BEHAVIOR INTERFACE. "We are just beginning to understand the wide influence exerted by the gut microbiota on brain and behaviour. However, it is already apparent that there is substantial overlap between the physiological relevance and behavioural impact of the gut microbiota, tryptophan metabolism and the serotonergic system." http://www.sciencedirect.com/science/article/pii/S0166432814004768 View in LinkedIn
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linkedin post 2020-01-17 03:58:09

linkedin post 2020-01-17 03:58:09

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MAZE SMART FUNGUS. "One species in particular, the SpongeBob SquarePants–yellow Physarum polycephalum, can solve mazes, mimic the layout of man-made transportation networks and choose the healthiest food from a diverse menu—and all this without a brain or nervous system. "Slime molds are redefining what you need to have to qualify as intelligent." http://www.scientificamerican.com/article/brainless-slime-molds/ View in LinkedIn
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linkedin post 2020-01-19 06:36:01

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FRESH EYES. “Such discrepancy would support the popular notion that brain evolution equates with development of the cerebral cortex, which comes to predominate over the other brain structures. However, analysis of absolute, rather than relative, cerebral cortical and cerebellar volumes in the same dataset leads to the opposite conclusion: the surface areas of these structures, would be evidence that the cerebral cortex and cerebellum are functionally related and have been evolving coordinately.” https://lnkd.in/d2aUKat View in LinkedIn
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linkedin post 2020-01-18 09:30:23

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CORTEX AND SIZE. “The increase in relative size of the cerebral cortex with increasing brain size simultaneously with no systematic change in the relative size of the cerebellum has been used as evidence that these structures are functionally independent and have been evolving separately.” https://lnkd.in/d2aUKat View in LinkedIn
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