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IMPACT ON MAN. “Human birth rates follow a robust circadian oscillation. Thus, between 2 a.m. and 6 a.m. about 1.8-fold more babies are born than between 2 p.m. and 6 p.m.” https://lnkd.in/dP8nvcG View in LinkedIn

WHEELS WITHIN WHEELS. “One recurring theme in clock mechanism is coupled transcription-translation feedback loops. To date, the majority of plant transcription factors constituting these loops. The circadian clock is an endogenous timekeeping mechanism that enables organisms not simply to respond as they experience environmental change but, importantly, to anticipate and prepare for coming change. This ability to coordinate with the environment enhances fitness in bacteria, plants, and animals.” https://lnkd.in/dAX4kdh View in LinkedIn

CLOCK REVIEW ARTICLE. “Circadian clocks have evolved to enhance adaptive physiology in the predictable, fluctuating environment caused by the rotation of the planet....major aspects of nutrient homeostasis, including carbon assimilation and mineral uptake, are under circadian control. It is also emerging that there is feedback of nutritional status to the circadian clock to integrate these processes. https://lnkd.in/dUkZXhu View in LinkedIn

LIVING GYROSCOPE. “Interactions between circadian clocks and photosynthesis for the temporal and spatial coordination of metabolism. A number of recent studies have demonstrated that the circadian clock is integrated very closely with photosynthesis and its metabolic products. We describe how this might provide adaptations to optimize plant performance in an environment that varies both predictably upon a daily and seasonal basis, and unpredictably due to the weather.” https://lnkd.in/dwMRFri View in LinkedIn

STILL UNRESOLVED. “Although endogenous control of rhythmic growth was described in oaks more than a century ago, the mechanisms involved have not yet been elucidated.” http://jxb.oxfordjournals.org/content/66/22/7113.full View in LinkedIn

OSCILLATOR NEURONS. “Suprachiasmatic nucleus (SCN) "itself is composed of ~20,000 neurons, each of which is thought to contain a cell autonomous circadian oscillator. The SCN functions as a network in which the population of SCN cells are coupled together and oscillate in a coherent manner." https://lnkd.in/dBQ96E6 View in LinkedIn

EMBEDDED CLOCKS. “Throughout the majority of the cells in the body, cell autonomous circadian clocks are intimately enmeshed within metabolic pathways.” https://lnkd.in/dBQ96E6 View in LinkedIn

ANATOMICAL LOCUS. “In the central suprachiasmatic nucleus (SCN) of the hypothalamus, a coupled population of neuronal circadian oscillators acts as a master pacemaker for the organism to drive rhythms in activity and rest, feeding, body temperature and hormones. Coupling within the SCN network confers robustness to the SCN pacemaker which in turn provides stability to the overall temporal architecture of the organism.” https://lnkd.in/dBQ96E6 View in LinkedIn