linkedin post 2020-07-21 05:03:29

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METABOLISM AND LIGHT. “Since the advent of electric lights around the turn of the 20th century, exposure to artificial and irregular light schedules has become commonplace. The increase in exposure to light at night parallels the global increase in the prevalence of obesity and metabolic disorders. In this review, we propose that exposure to light at night alters metabolic function through disruption of the circadian system.” https://lnkd.in/dH6Ha79 View in LinkedIn
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linkedin post 2020-07-22 04:39:46

linkedin post 2020-07-22 04:39:46

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CYCLIC NEUROPEPTIDES. “The timing of normal hypocretin/orexin production is critical as it contributes to staying awake (in humans typically later in the day) as sleep debt increases. In both humans and animals, absolute orexin deficiency is linked to the narcolepsy-cataplexy syndrome, while in animals a lack of orexin signaling increases risk of obesity.” http://www.biomedcentral.com/1741-7015/11/79 View in LinkedIn
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linkedin post 2020-07-22 04:36:26

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METABOLIC CUES. “In recent years, humans have shifted away from the naturally occurring solar light cycle in favor of artificial and sometimes irregular light schedules produced by electric lighting. Here we report that exposure to ecologically relevant levels of dim (5 lux) light at night altered core circadian clock rhythms in the hypothalamus at both the gene and protein level. Changes in the circadian clock were associated with temporal alterations in feeding behavior and increased weight gain. These results are significant because they provide evidence that mild changes in environmental lighting can alter circadian and metabolic function.” https://lnkd.in/d5Bk98R View in LinkedIn
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linkedin post 2020-07-22 04:34:41

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NIGHT OWL CONSEQUENCES. “Type 2 diabetes mellitus (T2DM) is complex metabolic disease that arises as a consequence of interactions between genetic predisposition and environmental triggers. One recently described environmental trigger associated with development of T2DM is disturbance of circadian rhythms due to shift work, sleep loss, or nocturnal lifestyle. However, the underlying mechanisms behind this association are largely unknown.” https://lnkd.in/diSfaUf View in LinkedIn
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linkedin post 2020-07-22 04:32:26

linkedin post 2020-07-22 04:32:26

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POSSIBLE MECHANISM. “While melatonin has not traditionally been considered to be a viable antidepressant alone, the registration of agomelatine in the European Union and internationally (but not in the USA) as a treatment for major depression has again raised questions as to whether melatonin itself has significant antidepressant properties.” http://www.biomedcentral.com/1741-7015/11/79 View in LinkedIn
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linkedin post 2020-07-22 04:30:30

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MELATONIN CYCLE. “In those with major depressive disorders, disturbances in the amplitude and rhythm of melatonin secretion have been described. These are similar to those described in a range of other sleep or neuropsychiatric disorders associated with disturbed circadian function.” https://lnkd.in/d8BtSnQ View in LinkedIn
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linkedin post 2020-07-22 04:28:23

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AUTHENTIC DISTURBANCE. “Sleep and circadian rhythm disruption (SCRD) is a common feature in many neuropsychiatric diseases including schizophrenia, bipolar disorder and depression. Although the precise mechanisms remain unclear, recent evidence suggests that this comorbidity is not simply a product of medication or an absence of social routine, but instead reflects commonly affected underlying pathways and mechanisms.” https://lnkd.in/dH79_u3 View in LinkedIn
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