linkedin post 2020-07-22 04:32:26

linkedin post 2020-07-22 04:32:26

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POSSIBLE MECHANISM. “While melatonin has not traditionally been considered to be a viable antidepressant alone, the registration of agomelatine in the European Union and internationally (but not in the USA) as a treatment for major depression has again raised questions as to whether melatonin itself has significant antidepressant properties.” http://www.biomedcentral.com/1741-7015/11/79 View in LinkedIn
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linkedin post 2020-07-22 04:30:30

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MELATONIN CYCLE. “In those with major depressive disorders, disturbances in the amplitude and rhythm of melatonin secretion have been described. These are similar to those described in a range of other sleep or neuropsychiatric disorders associated with disturbed circadian function.” https://lnkd.in/d8BtSnQ View in LinkedIn
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linkedin post 2020-07-22 04:28:23

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AUTHENTIC DISTURBANCE. “Sleep and circadian rhythm disruption (SCRD) is a common feature in many neuropsychiatric diseases including schizophrenia, bipolar disorder and depression. Although the precise mechanisms remain unclear, recent evidence suggests that this comorbidity is not simply a product of medication or an absence of social routine, but instead reflects commonly affected underlying pathways and mechanisms.” https://lnkd.in/dH79_u3 View in LinkedIn
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linkedin post 2020-07-21 05:11:06

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ACROSS TAXA. “It is important to note that exposure to light at night is not just a human issue. Many plant and animal species are affected by nighttime light exposure, as lighting from infrastructure strays into the atmosphere creating a general nighttime glow termed light pollution. Unnatural exposure to light at night may have significant ecological implications.” https://lnkd.in/dH6Ha79 View in LinkedIn
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linkedin post 2020-07-23 03:38:38

linkedin post 2020-07-23 03:38:38

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CLOCK AFFECTS ADME. “The sum of these daily circadian (24-h) and behavioral physiological patterns can therefore affect a medication’s bioavailability and duration of action through absorption, distribution, metabolism, and elimination.’ https://link.springer.com/article/10.1007/s11906-018-0897-4 View in LinkedIn
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linkedin post 2020-07-23 03:36:06

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CYCLIC FUNCTIONS. “The daily patterns of behaviors, including the sleep-wake, rest-activity, and fasting-feeding cycles, influence the daily fluctuations of gastric pH, gastric emptying, gastrointestinal transit time, organ blood flow, liver enzyme activity, and renal function.” https://lnkd.in/dK-Nfr2 View in LinkedIn
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