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SELECTOR GENES. “In the contemporary view, selector genes are distinguished from other TFs because they play a deterministic role in “selecting” the overarching developmental program for germ layers, developmental fields, lineage compartments, individual metameric units, or cell types.” (TF = transcription factors). https://lnkd.in/dfCi2dc View in LinkedIn

GENE TRIGGERS. “Here, gain or loss of single-selector genes invoke a shift in the total program for creation of a morphological structure; for example, the stable transformation of a leg into an antenna through loss of the homeobox (Hox) gene Antennapedia.” https://lnkd.in/dfCi2dc View in LinkedIn

METAMORPHOSIS. “Garcia-Bellido formulated the “selector gene” hypothesis to explain the effects of gene mutations that famously convert one body part into another.” https://lnkd.in/dfCi2dc View in LinkedIn

CANCER AND CLOCK GENES. “Therefore, preventing disruption of the circadian rhythm has the potential to improve the efficacy of cancer therapy. On the other hand, circadian rhythms could be reprogrammed in tumors.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND TUMORS. “Despite the arrhythmicity caused by double or triple knockdown, the interactive effects of these paralog genes in cancer remain to be ascertained. On one hand, loss of circadian homeostasis increases the risk of tumorigenesis in multiple cancer types.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK PARALOG GENES. “All 14 core clock genes have at least one paralog gene that may be functionally redundant in clock regulation. Composite knockdown of paralog clock genes may cause more serious consequences than single knockdown.” https://lnkd.in/dT2NKaY View in LinkedIn

PARALOG GENES. “Orthologous and paralogous genes are two types of homologous genes, that is, genes that arise from a common DNA ancestral sequence. Orthologous genes diverged after a speciation event, while paralogous genes diverge from one another within a species.” https://lnkd.in/dUyuDhw View in LinkedIn

TUMOR TRIGGERS. “Dysregulation of clock genes promotes tumorigenesis through mechanisms that include the cell cycle, DNA damage, and metabolism.” https://lnkd.in/dT2NKaY View in LinkedIn

Transformation of leaf form during maturation. It begs the functional question, whose answer is not obvious. View in LinkedIn

TO START AT THE BEGINNING. “To develop cancer chronotherapy, the first crucial step is to understand the roles of clock genes in cancer. The mammalian circadian machinery is controlled by two main transcriptional/translational auto-regulatory feedback loops that involve 14 core clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn