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CLOCK PARALOG GENES. “All 14 core clock genes have at least one paralog gene that may be functionally redundant in clock regulation. Composite knockdown of paralog clock genes may cause more serious consequences than single knockdown.” https://lnkd.in/dT2NKaY View in LinkedIn

PARALOG GENES. “Orthologous and paralogous genes are two types of homologous genes, that is, genes that arise from a common DNA ancestral sequence. Orthologous genes diverged after a speciation event, while paralogous genes diverge from one another within a species.” https://lnkd.in/dUyuDhw View in LinkedIn

ALBERT DÜRER. https://lnkd.in/dcnXNHB View in LinkedIn

THERAPEUTIC PROFILING. “Tumor subtype information often provides crucial insights to help stratify patients for predicting prognosis and selecting effective treatments. We identified 43 clock genes differentially expressed among different cancer subtypes.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND STAGING. “We further identified 23 clock genes that were differentially expressed among tumor stages. These results suggest the potential involvement of clock genes in tumor progression.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENES AND SURVIVAL. “Given the global alterations of clock genes in cancer, clock genes could provide important insight for translational medicine. Here, we focused on clock genes that showed significant associations with patient survival, clinical stage, or tumor subtype. We identified 31 clock genes that were associated with overall patient survival in at least one cancer type.” https://lnkd.in/dT2NKaY View in LinkedIn

CLOCK GENE DYSFUNCTION. “We sought to systematically investigate the contributions of circadian rhythm disruption and impaired molecular clockworks to tumorigenesis. Several thousand genes lost their correlation to clock genes in tumor samples. We also found that correlation among core clock genes was reduced significantly.” https://lnkd.in/dT2NKaY View in LinkedIn

CELL LINE STUDIES. “To further investigate the potential effects of clock genes on drug sensitivity, we examined the correlation between transcriptional expression of clock genes in the Cancer Cell Line Encyclopedia dataset and drug sensitivity in the CTRP dataset.” https://lnkd.in/dT2NKaY View in LinkedIn

POWERFUL REGULATOR. “DNA methylation regulates gene expression in cancer. We examined the promoter DNA methylation patterns of clock genes across different cancer types and observed an overall negative correlation between DNA methylation and gene expression (Figure S3A). We further observed multiple small alterations with a few genes showing differentially methylated patterns.” https://lnkd.in/dT2NKaY View in LinkedIn

GENES AND MEDICINES. “For drugs with known targeted genes, we further estimated the correlations between targeted genes and clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn