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BROAD STUDY. “To further evaluate the potential effects of clock genes on drug response, we analyzed the correlation between drug sensitivity of 265 anti-cancer drugs and transcriptional expression of 51 clock genes across 1,080 cancer cell lines from GDSC using the Z score as described previously.” https://lnkd.in/dT2NKaY View in LinkedIn

DRUG TARGETS. “Many clinically actionable genes are targeted by anti-cancer drugs. Thus, following circadian timing for drug administration may largely improve the efficacy of a drug and reduce its toxicity.” https://lnkd.in/dT2NKaY View in LinkedIn

PLANT TRANSITION TO DRY LAND. "Plants faced precisely the same problem: that of the pteridophytic life cycle with its free-living gametophytes and swimming sperm in need of freestanding water, being dragged from their supportive environment by the increasingly complex sporophytic adaptations to life on land." https://lnkd.in/d8znE3J View in LinkedIn

FRAGMENT FROM NATURE explores the ancient transition of plants from the water to dry land, and then those that returned to water. Those plants that re-adapted to salt water are the focus of this fragment. These transitions involved considerable changes in metabolism, in particular respiration, which involved biochemical ingenuity, and involved reproductive challenges, These changes opened up new habitats, thus expanding their territorial reach, and ultimately led to the remarkable success of plants. View in LinkedIn

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CLINICAL CORRELATES. “We further showed that transcriptional dysregulation of clock genes is strongly associated with patient survival, tumor stage and subtype.” https://lnkd.in/dT2NKaY View in LinkedIn

DYSREGULATION. “We revealed disruption of circadian rhythms across patient samples by showing significantly reduced number of genes correlated to clock genes.” https://lnkd.in/dT2NKaY View in LinkedIn

MULTIPLE PATHWAYS. "Aquatic plants are an extremely heterogeneous assemblage of species that survive in similar habitats but as a result of fundamentally different evolutionary pathways." https://lnkd.in/dAT9Bid View in LinkedIn

YIN YANG. “Our results suggested several clock genes may function as oncogenes...while several other clock genes may function as tumor suppressors.” https://lnkd.in/dT2NKaY View in LinkedIn