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Very early evidence of the use of glasses (Lyon Art Museum). View in LinkedIn

SAND CASTLES. “I consider it quite possible that physics cannot be based on the field concept, i.e. on continuous structures. In that case, nothing remains of my entire castle in the air, gravitation theory included, and of the rest of modern physics." (Einstein). https://lnkd.in/ej5vMhyF View in LinkedIn

TOXIC OXYGEN RADICALS. “Notably, dampened melatonin secretion caused by sleep disruption may increase reactive oxygen species (ROS) levels and reactive nitrogen species (RNS) production, as suggested by studies in night-shift workers.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

MITOCHONDRIAL EFFECTS. “Interestingly, melatonin regulates the mitochondrial respiratory complexes I and IV and thereby modulates ATP production. Therefore, melatonin may antagonize the glycolytic dependency of cancer cell metabolism in a time-dependent manner by targeting mitochondrial function.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

DOWNSTREAM EFFECTS. “Melatonin has been linked to regulation of oxidative stress mostly in the mitochondria, where melatonin is reported to stimulate the activity of glutathione peroxidase (GPx) and glutathione reductase (GRd), two enzymes involved in regulation of the glutathione:glutathione disulfide ratio.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCK HORMONE. “One such link has been made with melatonin, a hormone produced by the pineal gland in a circadian manner to regulate sleep.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ENDOCRINE NETWORKS. “Interestingly, several lines of epidemiological evidence connecting circadian disruption due to shift work with cancer have largely focused on hormone-dependent diseases such as breast and prostate cancer, which raises the possibility that additional clock-controlled endocrine factors may be at play.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

INTERCONNECTED SYSTEMS. “These studies establish an intriguing link between the transcriptional networks of the clock system with HIF1α and potentially suggest that this crosstalk could be involved in the hypoxic response during tumorigenesis.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

FUTURE WORK. “Therefore, further investigation is required to determine the role of nutritional inputs on circadian metabolism and tumorigenesis.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

METABOLIC FACTORS. “Also, metabolomics analyses in human serum, plasma, and skeletal muscle have identified major populations of rhythmic metabolites over the circadian cycle.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn