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SO ENDS this second and last weekend on an article about cancer and the cellular clock. Since circadian rhythms control a great number of cellular and behavioral events, dysfunctional clocks will inevitably have a plethora of effects, and contributing to initiating oncogenesis is no surprise. However, the evidence presented here and elsewhere show this dysfunction at a molecular and genetic level of granularity. https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CORRELATION. “The complex network of communication between the circadian clock and tumorigenesis is only beginning to be unraveled (Fig. 3). At the foundation is strong epidemiological evidence that implicates circadian disruption with cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

RX TIMING. “This so-called ‘chronotherapy’ has been recently reviewed in depth, and evidence strongly supports the idea that metabolic and xenobiotic detoxification enzymes exhibit temporal peaks in activity and thus should be pharmacologically targeted based on optimal time of day.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

ANTIMATTER QUARKS. “Their fleeting existence makes the antimatter quarks within protons difficult to study, but their existence is discernible in reactions in which a matter–antimatter quark pair annihilates.” https://www.nature.com/articles/s41586-021-03282-z View in LinkedIn

TREATMENT ISSUE. “The multiple connections discussed here between clock disruption and cancer beg the question of whether circadian therapeutic intervention (such as time of day) should be considered for treatment of cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

READ CAREFULLY. “An essential feature of this force, as described by quantum chromodynamics, is its ability to create matter–antimatter quark pairs inside the proton that exist only for a very short time.” https://www.nature.com/articles/s41586-021-03282-z View in LinkedIn

RECYCLING CLOCK. “Also, it is possible that tumor-dependent metabolic waste may be secreted in a temporal manner, suggesting peak times of day whereby these metabolic pathways could be targeted pharmacologically.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

OLD PICTURE. “Several authors assumed that at some low momentum scale the sea quarks and gluons vanish, and at high momentum scales they are all generated by gluon radiation and then gluon splitting. These assumptions were used to describe successfully the existing data in the late 1970s.” https://www.nature.com/articles/s41586-021-03282-z View in LinkedIn

Tinkering with nonsense can lead you down unexpected rabbit holes leading to unimagined worlds. Just see where these paths lead! View in LinkedIn

MEMORY + IMAGINATION. “One might think that remembering the past is merely an act of recall. However, emerging research suggests that memory construction underlies imaginative thinking because humans are not able to “play back” the past like a movie-reel, but instead must cobble together a likely rendering of past events based on educated, imagined guesses.” (Lovely article). https://lnkd.in/dXnTq46Z View in LinkedIn