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WHEN? "And in terms of when we can expect utility fogs to make their appearance, Hall says it should come about in the neighborhood of around 2030 — but no later than 2040. "Any later than that," said Hall, "and I would be profoundly disappointed." https://lnkd.in/eik9_rZ View in LinkedIn

BACTERIA AND VDR. "Vitamin D receptor (VDR) plays an essential role in gastrointestinal inflammation. Most investigations have focused on the immune response; however, how bacteria regulate VDR and how VDR modulates the nuclear factor (NF)-κB pathway in intestinal epithelial cells remain unexplored." https://lnkd.in/eRmcyfQ View in LinkedIn

AUTOPHAGY AND VDR. "The functions of autophagy include tumor suppression, antimicrobial defense, inhibition of cardiac hypertrophy, anti-aging, and others. Remarkably, the functions of autophagy overlap with those of the vitamin D/VDR signaling." https://lnkd.in/eD6Q7PW View in LinkedIn

VDR ACTIVATION AFFECTS AUTOPHAGY. "Autophagy influences various aspects of disease progression, including stress adaptation, lifespan extension, development, immunity, and cancer." https://lnkd.in/eD6Q7PW View in LinkedIn

VITAMIN D RECEPTOR (VDR). "Activation of VDR signaling affects many processes, including calcium metabolism, apoptosis, immunity, and autophagy." https://lnkd.in/eD6Q7PW View in LinkedIn

"VITAMIN D DEFICIENCY is a critical factor in the pathology of at least 17 varieties of cancer, as well as autoimmune diseases, diabetes, osteoarthritis, periodontal disease, and more. Vitamin D receptor (VDR) is a nuclear receptor that mediates most biological functions of vitamin D3, the active form of vitamin D." https://lnkd.in/eD6Q7PW View in LinkedIn

L-FORMS AND VITAMIN D DYSREGULATION. "Vitamin D research is discussed in light of the hypothesis that the lower average levels of vitamin D frequently observed in autoimmune disease are not a sign of deficiency. Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes." https://lnkd.in/eRQEiar View in LinkedIn

ALTERNATIVE TO GENETIC THEORY. "There is also evidence to suggest that L-forms can survive within the ovum and sperm and also that they can pass through the placental barrier, meaning that illnesses that run in families may be infective rather than genetic in nature. The infant can also acquire infections at or after birth, before their adaptive immune system is up and running." https://lnkd.in/dTCkxDw View in LinkedIn

BACTERIAL PERSISTENCE. "Essential to the thesis is that small, electron dense, non-vesiculated L-forms are the central (core) element in bacterial persistence. Depending on the stimulus received, these dense forms might be considered as undifferentiated cells, with the capacity to develop along several different routes." http://www.discoverymedicine.com/Gerald-J-Domingue/2010/09/23/demystifying-pleomorphic-forms-in-persistence-and-expression-of-disease-are-they-bacteria-and-is-peptidoglycan-the-solution/ View in LinkedIn

FRAGMENT FROM NATURE this weekend continues with the mysterious L-form bacteria, and their curious link to vitamin D metabolism. Some serious scientists have speculated that this nexus is the cause of a number of chronic illnesses, while others have gone as far as to develop untested treatment methods based on this hypothesis. View in LinkedIn