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AN OLD THERAPY COMES OF AGE. Impediments to FMT include: "It is aesthetically unappealing, it is logistically challenging (in terms of harvesting and processing suitable donor material), and there is a lack of efficacy data from randomized, controlled trials." https://lnkd.in/e92WcxV View in LinkedIn

"SYSTEMATIC REVIEW: faecal microbiota transplantation in the management of inflammatory bowel disease. Whilst the available evidence is limited and weak, it suggests that faecal microbiota transplantation has the potential to be an effective and safe treatment for IBD, at least when standard treatments have failed. Well-designed randomised controlled trials are required to investigate these findings." https://lnkd.in/edRQD5H View in LinkedIn

FECAL TRANSPLANTS (FMT). "The rationale behind FMT is simple: antibiotics and other factors disrupt the normal balance of colonic flora and reduce "colonization resistance", allowing pathogenic C. Difficle strains to grow...by reintroducing flora via donor feces, the imbalance can be corrected, the cycle interrupted, and normal bowel function re-established." https://lnkd.in/erygCxw View in LinkedIn

C. DIFFICILE FMT REVIEW. "In 317 patients treated across 27 case series and reports, FMT was highly effective, showing disease resolution in 92% of cases. Effectiveness varied by route of instillation, relationship to stool donor, volume of FMT given, and treatment before infusion. Death and adverse events were uncommon." https://lnkd.in/eymWM_R View in LinkedIn

C. DIFFICILE. "Fecal microbiota transplantation (FMT) is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured." Cured with a single treatment. https://lnkd.in/erygCxw View in LinkedIn

"CLOSTRIDIUM DIFFICILE INFECTION is increasing in incidence, severity and mortality. Treatment options are limited and appear to be losing efficacy." https://lnkd.in/erygCxw View in LinkedIn

FECAL REVERSAL OF METABOLIC SYNDROME. "Obese patients with a constellation of symptoms known as metabolic syndrome improved insulin sensitivity with fecal transplants from healthy thin donors" in just six weeks (n=18, p

FIGHTING OBESITY WITH BACTERIA. "The microbiota from lean or obese humans induces a similar phenotype in mice and, more remarkably, that the microbiota from lean donors can invade and reduce adiposity gain in the obese-recipient mice if the mice are fed an appropriate diet." https://lnkd.in/eddH2Fj View in LinkedIn

MERCOLA ON FMT. "It is highly probable that many of our modern diseases are the end result of a dramatic disconnect from the natural world, which teems with microbiota, as predicted by the so-called Hygiene Hypothesis." https://lnkd.in/e6YrYYR View in LinkedIn

DIY FMT AND CRAPSULES. "Their latest venture is in capsules containing faeces. Similar products have been trialled successfully by researchers at the University of Calgary and Ilan Youngster is currently working on a further study. Thomas Borody also uses them - he calls them "crapsules". Taking faecal tablets, although still revolting as a concept, is less invasive than a colonoscopy or enema." https://lnkd.in/e_6wSXz View in LinkedIn