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CURIOUS TEMPERATURE FLEXIBILITY. "TRPA1 is arguably the most fascinating TRP ion channel...as orthologs from different species demonstrate opposite temperature directionality." Some for heat, some for cold. https://lnkd.in/egjk4Ss View in LinkedIn

TRPA1 "can transform the mechanical stimulus of a sound wave into an electrical signal recognizable by the brain. The protein forms an ion channel that opens in response to sound, causing electrical impulses that communicate the pitch, volume, and duration of a sound to the brain." https://lnkd.in/eCrD8Q8 View in LinkedIn

EXTRAORDINARY MULTIFUNCTIONALITY. "TRPA1 has become one of the most intensively studied ion channels. Its function has been linked to regulation of heat and cold perception, mechanosensitivity, hearing, inflammation, pain, circadian rhythms, chemoreception, and other processes." https://lnkd.in/erPHnzY View in LinkedIn

MULTI-TASKING. "TRPs are multitasking proteins, and second, many functions and modes of activation of these channels are evolutionarily conserved, including some that were formerly thought to be unique to invertebrates, such as phototransduction." https://lnkd.in/ee5Y9gz View in LinkedIn

WASABI RECEPTOR is yet another name for TRPA1, see this nice 3D reconstruction of the molecule. https://lnkd.in/ePnxtdx View in LinkedIn

VARIOUS STIMULI. "A truly polymodal ion channel, TRPA1 is activated by various stimuli, including electrophilic chemicals, oxygen, temperature, and mechanical force, yet the molecular mechanism of TRPA1 gating remains obscure." https://lnkd.in/erPHnzY View in LinkedIn

TRP FAMILY. "Several dozen TRP channels have been identified and are classified into six subfamilies, including the TRP ankyrin family (TRPA), with varying degrees of sequence similarity and permeability to cations. TRPA1 is the only member of the ankyrin subfamily so far identified in mammals, and it contains at least 14 ankyrin repeats in the N-terminal intracellular domain." https://lnkd.in/ecaVp5Q View in LinkedIn

STRUCTURAL RELATIVES. "Transient receptor potential (TRP) channels are diverse six-transmembrane domain (6-TM) cation channels that are related to, and share, the transmembrane topology and functional domain structure of the tetrameric voltage-gated ion channels." https://lnkd.in/ecaVp5Q View in LinkedIn

SEEING THROUGH WALLS. "We propose to use transformation optics to generate a general illusion such that an arbitrary object appears to be like some other object of our choice." https://lnkd.in/eyBstN6 View in LinkedIn

SUPERFAMILY. "These channels are classified into subfamilies, namely canonical (TRPC), melastatin (TRPM), ankyrin (TRPA), and vanilloid (TRPV). Some of these channels are activated by heat (TRPM2/4/5, TRPV1-4), while others by cold (TRPA1, TRPC5, and TRPM8)." https://lnkd.in/eZQCjnY View in LinkedIn