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ANTAGONISTS. "The importance of TRPA1 in pain signaling makes it a potential target for the treatment of pathological pain. While some small-molecule TRPA1 antagonists have been identified, no peptide antagonists of TRPA1 have been reported." https://lnkd.in/ecaVp5Q View in LinkedIn

BLOCKING TRPA1. "Genetic deletion or pharmacological blockade of TRPA1 produces inhibitory activity in mouse models of anxiety and depression. These results imply that TRPA1 exerts tonic control, promoting anxiety and depression, and that TRPA1 antagonism has potential as an innovative strategy for the treatment of anxiety and mood disorders." https://lnkd.in/e-Efbhd View in LinkedIn

PSYCHIATRIC LINK. "Transient receptor potential vanilloid 1 (TRPV1) and TRP ankyrin 1 (TRPA1) are involved in many biological processes, including nociception and hyperalgesia. Whereas the involvement of TRPV1 in psychiatric disorders such as anxiety and depression has been reported, little is known regarding the role of TRPA1 in these conditions." https://lnkd.in/e-Efbhd View in LinkedIn

ROLE IN PAIN. "A clear role for TRPA1 in pain transduction is established...Furthermore, the role of TRPA1 in pain signaling is underscored by its involvement in an autosomal familial episodic pain syndrome, migraine headaches, and other human pain disorders." https://lnkd.in/e-WBvC9 View in LinkedIn

TRIGGERED ALARM RESPONSE. "Activation of TRPA1 can cause extreme irritation, lacrimation, coughing, bronchial contraction and depressed respiration. Therefore, potent electrophilic compounds (for example, 1-chloroacetophenone, dibenz[b,f][1,4]-oxazepine, 2-chlorobenzylidene malononitrile, and chloropicrin) are used as tear gases and riot control agents." https://lnkd.in/e-WBvC9 View in LinkedIn

EXTERNAL AND INTERNAL ALARM. "The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug metabolism. These include a broad class of electrophiles that activate the channel through covalent protein modification." https://lnkd.in/evaGrBq View in LinkedIn

THERMOREGULATION. "TRP channels are expressed in thermoregulatory effector organs, such as adipose tissue, muscle, vasculature and gastrointestinal tract, thereby potentially modulating the metabolic status." https://lnkd.in/ekDF8xf View in LinkedIn

METABOLIC ROLE. "Since many TRP channels are functionally implicated in sensory systems, it is thus not surprising to discover their direct (or indirect) modulatory role in the context of metabolic regulation." https://lnkd.in/ekDF8xf View in LinkedIn

SENTINEL MOLECULE. "The non-selective cation channel TRPA1...is perhaps the most versatile of all polymodal sensory ion channels. Different TRPA1 orthologues were reported to mediate the detection of cold, heat and noxious chemicals, such as allyl isothiocyanate (AITC), the pungent agent from wasabi and other mustard plants." https://lnkd.in/eFfEp_R View in LinkedIn

MANY ACTIVATORS. "TRPA1 can also be activated by endogenous metabolic products and oxidative stress-derived substances and sensitized through G protein-coupled receptors (GPCRs), cyclic adenosine monophosphate/protein kinase A (cAMP/PKA), and protease activated receptor 2 (PAR2) signaling pathways." https://lnkd.in/ecaVp5Q View in LinkedIn