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NORMAL PRION PROTEIN ISOFORMS. "PrP is a perfectly normal protein produced by nerve cells. When the cell needs more PrP protein, the gene that codes for PrP gets "turned on" and a new PrP molecule is synthesized. Inside the cell, PrP gets folded into its normal three-dimensional configuration. It's then excreted and anchored to the outside of the nerve cell, where it is believed to play a role in synaptic function." http://www.strangehorizons.com/2004/20040216/killer.shtml View in LinkedIn

"THE TWO ISOFORMS of the PrP protein are technically designated PrPC and PrPSc. The "C" stands for cellular; the "Sc" stands for scrapie. PrPSc is believed to be the main, and probably the only, component of the prion (a term derived from "proteinaceous infectious particle")." https://lnkd.in/ekPJGXx View in LinkedIn

DNA INDEPENDENT. "Prion diseases are caused by conversion of a normal cell-surface glycoprotein (PrPC) into a conformationally altered isoform (PrPSc) that is infectious in the absence of nucleic acid." https://lnkd.in/eJBJ5gT View in LinkedIn

"PRIONS are not considered living organisms because they are misfolded protein molecules which may propagate by transmitting a misfolded protein state. If a prion enters a healthy organism, it induces existing, properly folded proteins to convert into the misfolded prion form. In this way, the prion acts as a template to guide the misfolding of more proteins into prion form." https://en.m.wikipedia.org/wiki/Prion View in LinkedIn

ROGUE PROTEIN ISOFORMS. "The best-known attribute of the prion protein (PrP) is its tendency to misfold into a rogue isoform. Neurodegeneration in prion disease is often seen as a consequence of abnormal PrP function yet, amazingly little is known about the normal, physiological role of PrP. In particular, the absence of obvious phenotypes in PrP knockout mice has prevented scientists from answering this important question." https://lnkd.in/eBQR5Bd View in LinkedIn

PRIONS LACK DNA AND RNA. "A prion in the Scrapie form (PrPSc) is an infectious agent composed of protein in a misfolded form. This is the central idea of the Prion Hypothesis, which remains debated. This would be in contrast to all other known infectious agents (virus/bacteria/fungus/parasite)—which must contain nucleic acids (either DNA, RNA, or both)." https://lnkd.in/eAmJb_G View in LinkedIn

PRIONS TEMPLATE NORMAL PROTEINS. "These newly formed mis-folded proteins, in turn, act as further templates for the conversion of more normal proteins, leading to an exponential accumulation of prions in the tissue of the central nervous system. These abnormally folded proteins form plaques which are thought to cause "entanglement" of neurofibrils and interfere with synapse function." https://lnkd.in/e6wAxB5 View in LinkedIn

"PRIONS are the only known infectious agents that do not contain DNA or RNA." https://lnkd.in/e7FiuTa View in LinkedIn

PRIONS, ABNORMALLY FOLDED PROTEINS. "A prion is composed of abnormally folded protein that causes progressive neurodegenerative conditions. These mis-folded proteins do not multiply in the host organism that they infect. Instead, they affect the brain structure by acting as a template, inducing proteins with normal folding to convert to the abnormal prion form." https://lnkd.in/e6wAxB5 View in LinkedIn

THE PRION HYPOTHESIS instead "claims that there is a source of information within protein molecules that contributes to their biological function, and that this information can be passed on to other molecules. But the protein molecules are still manufactured according to the instructions contained in nucleic acid. The additional information source is the conformation or shape of the protein molecule." https://lnkd.in/e4dnA_x View in LinkedIn