linkedin post 2016-02-06 05:37:27
"SUPER ENHANCERS are enhancer-dense regions found near genes that play key roles in determining cellular identity." https://lnkd.in/eBuSbSN View in LinkedIn
linkedin post 2016-02-07 06:05:54
DECODING JUNK DNA. "In a paper published in Nature in 2012, ENCODE researchers concluded that 80% of the human genome is functional. Ever since, commentators have argued over what large swaths of non-coding DNA might be doing. Super-enhancers, which can occupy tens of kilobases, suggest a use for at least some of this DNA. In fact, published ENCODE work foreshadowed the super-enhancer discovery." https://lnkd.in/ezRUFD5 View in LinkedIn
linkedin post 2016-02-07 06:02:31
SYROS PHARMACEUTICALS: "blocking of a few master genetic switches associated with “super enhancers” might be a simple cure for cancer, says Dr. Richard Young, of Whitehead research institute" and founder of Syros. They raised $83.1 M in two rounds, https://lnkd.in/eSdUNqN View in LinkedIn
linkedin post 2016-02-07 05:58:58
ENHANCER CLUSTERS. "You might say that cancer cells are “fueled” by “super enhancers”, and might suggest inhibiting such a fueling source to cure cancer and you might be correct to be hopeful, albeit with a heavy dose of patience. Last year it was discovered there are a million enhancers in the human genome. Dr Young speculates that some of these enhancers act together in large clusters and function as a unit." https://lnkd.in/eSdUNqN View in LinkedIn
linkedin post 2016-02-07 05:55:46
HOLY GRAIL. "For years cancer scientists have been reporting their discoveries of the mediators responsible for over expression of cancer genes. What makes Dr Young’s work more unique is that it suggests that a few master switches might control this gene at super enhancer regions. There are thousands of cancer gene transcription factors in the literature." https://lnkd.in/eSdUNqN View in LinkedIn
linkedin post 2016-02-07 05:53:27
TUMOR "acquisition of specific super-enhancers presumably results from chromosomal translocation, gene amplification, increased transcription factor expression, or somatic mutation of noncoding elements, all of which are known to contribute to tumorigenesis. Interestingly, genomic rearrangements can also contribute to tumorigenesis by simultaneous ectopic transcriptional activation and haploinsufficiency during super-enhancers transitions." https://lnkd.in/exFAp7h View in LinkedIn
linkedin post 2016-02-07 05:51:39
ENHANCER ENRICHED. "Cancer cells acquire super-enhancers to drive high level transcription of oncogenes, and sequence variation associated with other diseases is especially enriched in super-enhancers." https://lnkd.in/e5vj59F View in LinkedIn
linkedin post 2016-02-07 05:48:26
NEW DIAGNOSTICS AND THERAPEUTICS. "Super-enhancers can be used as potential biomarkers for disease diagnosis and therapeutics. Current studies have identified super-enhancers in more than 100 cell types and demonstrated their functional importance." https://lnkd.in/eSAYCfF View in LinkedIn
linkedin post 2016-02-07 05:46:54
"ENHANCED ENHANCERS. The recent discovery of super-enhancers may offer new drug targets for a range of diseases." https://lnkd.in/esCre5j View in LinkedIn
linkedin post 2016-02-06 05:54:16
"SEA: a super-enhancer archive. The current release of SEA incorporates 83,996 super-enhancers computationally or experimentally identified in 134 cell types/tissues/diseases." This appears to be an ungovernable committee of genes. http://nar.oxfordjournals.org/content/early/2015/11/16/nar.gkv1243.full View in LinkedIn