linkedin post 2016-03-19 05:45:50

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AGENTS OF CELL DEATH. "Depending upon the need, a virus may inhibit or induce apoptosis for the obvious purpose of replication and spread, respectively. Interference in mitochondrial function can cause either cell death due to deregulation of the Ca2+ signaling pathways and ATP depletion or apoptosis due to regulation of Bcl-2 family proteins. Apoptosis is a programmed cell death." https://lnkd.in/eFuy4KS View in LinkedIn
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linkedin post 2016-03-19 05:43:43

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STRESS AND MITOCHONDRIA. "During stress conditions, a small fraction of electrons leave complex III and reach complex IV. This premature electron leakage to oxygen results in the formation of two types of superoxides, namely, in its anionic form, and in its protonated form." https://lnkd.in/eFuy4KS View in LinkedIn
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linkedin post 2016-03-19 05:41:16

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TOXIC REACTIVE OXYGEN SPECIES (ROS). "The mitochondrial respiratory chain is the main and most significant source of reactive oxygen species (RO) in the cell. Superoxide is the primary ROS produced by mitochondria. In the normal state, there is little or no leakage of electrons between the complexes of the electron transport chain." https://lnkd.in/eFuy4KS View in LinkedIn
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linkedin post 2016-03-19 05:36:16

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INTIMATE RELATIONSHIP. "Perhaps nowhere in nature is a parasitic relationship as well defined as that which occurs between a virus and its host cell. Viruses rely on the host cell for propagation, utilizing cellular machinery for the replication and assembly of viral components and the release of progeny virions." https://lnkd.in/esrit55 View in LinkedIn
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linkedin post 2016-03-19 05:27:33

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FRAGMENT FROM NATURE continues from last weekend about the battle between virus and its host for control of the host's cellular machinery, which is obligatory to allow the virus to enter, replicate, and thrive. The sophistication of the molecular strategies employed by viruses to evade host defenses is evidence of a vibrant adaptive response by the virus, forever probing endless new possibilities via intense genetic variation. View in LinkedIn
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linkedin post 2016-03-18 04:23:17

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THREE FLIES IN THE OINTMENT. "The fact that there is a direct relationship between the structure of the complex macromolecules involved in retroviral replication and their function has long been clear. Three factors complicate the correlation of retroviral nucleic acid sequence with their encoded proteins: ribosomal frameshifting, readthrough suppression of termination codons, and splicing, which is, in some cases, quite complex." https://lnkd.in/eBisbvi View in LinkedIn
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linkedin post 2016-03-20 06:42:19

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WHOLESALE REDISTRIBUTION. "Viruses alter the intracellular distribution of mitochondria either by concentrating the mitochondria near the viral factories to meet energy requirements during viral replication or by cordoning off the mitochondria within cytoplasm to prevent the release of mediators of apoptosis." https://lnkd.in/eFuy4KS View in LinkedIn
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