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CROSS-KINGDOM REGULATION. "Since a plant miRNA (miR168) cross-regulating a mammalian transcript was reported, miRNA-mediated cross-kingdom communication has become one of the most compelling but controversial topics." https://lnkd.in/ecyjYr4 View in LinkedIn

MICRO-RNAS IN FOOD. "microRNAs have been extensively discovered in various dietary resources including plants (e.g. rice and tomato) and animals (e.g. milk and meats). Given the broad implications of microRNA in health and disease, research enthusiasm for functional impacts of exogenous food microRNA in human cellular phenotypes has soared." https://lnkd.in/ej7XF-E View in LinkedIn

EXTRACELLULAR POPULATION. "According to current knowledge, extracellular miRNAs may be actively secreted by donor cells via membranous vesicles, or just merely by-products of cell death and released passively into the outer space after the cell membranes lose integrity." https://lnkd.in/ejyM8yt View in LinkedIn

MASSIVE EFFECTORS. "In animal cells, miRNAs inhibit translation or stability of mRNA transcripts by binding to them with largely imperfect complementarity. By recognition of hundreds of mRNA transcripts, a single miRNA can shift the entire transcription profile of a cell, consistent with a pivotal role for miRNAs in establishing and maintaining tissue identity." https://lnkd.in/eci-H_v View in LinkedIn

BIG PICTURE. "We analyzed all publicly available microRNAs, a total of 34,612 from 194 species, with 1,102 features derived from the microRNA sequence and structure. Through in-depth bioinformatics analysis, 8 groups of discriminative features have been used to characterize human circulating microRNAs and infer the likelihood that a microRNA will get transferred into human circulation." https://lnkd.in/eVc5i_G View in LinkedIn

TARGETING 60% OF GENES. "In human, 2,588 known miRNAs (according to miRBase v21) have been estimated to target ~60% of human genes and regulate a vast array of fundamental cellular processes in different cell types." https://lnkd.in/eVc5i_G View in LinkedIn

OVERLOOKED. "MicroRNAs have been long considered synthesized endogenously until very recent discoveries showing that human can absorb dietary microRNAs from animal and plant origins while the mechanism remains unknown. Since miRNAs have been long considered to be synthesized endogenously, little has been studied on miRNA cross-species transportation during the past decade." https://lnkd.in/eVc5i_G View in LinkedIn

"HORIZONTAL TRANSFER of Small RNAs to and from Plants. Many studies have reported the introduction of cross-kingdom sRNAs between animals and parasites. For example, miRNAs traffic from human sickle cells to malarial parasites and from helminth nematodes to mouse cells." https://lnkd.in/eqwgs-g View in LinkedIn

HORIZONTAL GENE TRANSFER. "Accumulating evidence has demonstrated that miRNAs, once thought to be unstable molecules, are stable and can be horizontally transferred across species and kingdoms." Bingo. https://lnkd.in/ejyM8yt View in LinkedIn

STABILITY. "While naked microRNAs are highly unstable and are quickly degraded by omnipresent RNases several papers note that circulating microRNAs in blood and various body fluids are highly stable which predisposes them as a potential biomarker for malignant and non-malignant diseases." https://lnkd.in/erkHGt5 View in LinkedIn