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PLANT HOMOLOG AND TUMORS. "We found that Western donor sera contained the plant miRNA miR159, whose abundance in the serum was inversely correlated with breast cancer incidence and progression in patients. Oral administration of miR159 mimic significantly suppressed the growth of xenograft breast tumors in mice. These results demonstrate for the first time that a plant miRNA can inhibit cancer growth in mammals." https://lnkd.in/e_qsx9z View in LinkedIn

HOMOLOGS ACROSS KINGDOMS. "Some of the predicted plant miRNAs have functional homology to their mammalian counterparts and regulated human genes when they were transfected into cell lines." https://lnkd.in/eBr8GUp View in LinkedIn

DIET AND ENVIRONMENT. "The influence of diet and environment on human health has been known since ages. Plant-derived natural bioactive compounds (phytochemicals) have acquired an important role in human diet as potent antioxidants and cancer chemopreventive agents." All Epigenetic phenomena. https://lnkd.in/eQPpbvk View in LinkedIn

"A NON-CODING RNA (ncRNA) is a functional RNA molecule that is transcribed from DNA but not translated into proteins. Epigenetic related ncRNAs include miRNA, siRNA, piRNA and lncRNA." http://www.whatisepigenetics.com/non-coding-rna/ View in LinkedIn

BREAST MILK. "A high number of microRNAs in human breast milk are present in microvesicles or exosomes which protect them from rapid degradation by RNases. It has been proposed that microRNAs are involved in cell–cell communication and play an important role in the immune system maturation of the infant." https://lnkd.in/erkHGt5 View in LinkedIn

EXPANDING RANGE OF TAGS. "There are epigenetic marks that cluster around the start points of genes; there are marks that cover long stretches of DNA, and others that affect much shorter regions; there are even epigenetic modifications of RNA." https://www.theguardian.com/science/occams-corner/2014/apr/25/epigenetics-beginners-guide-to-everything View in LinkedIn

STABLE MiRNAs. "It has been demonstrated by high-throughput sequencing that certain miRNAs from plants such as Zea mays (Z. mays), Arabidopsis thaliana (A. thaliana), Oryza sativa (O. sativa), and Citrus trifoliate (C. trifoliate) can exist stably in human plasma and breast milk exosomes, including 35 miRNAs from 25 MIR families." https://lnkd.in/eqwgs-g View in LinkedIn

EPIGENETIC TAGS. "Methyl groups and other small molecular tags can attach to different locations on the histone proteins, each one having a different effect. Some tags in some locations loosen the attachment between the DNA and the histone, making the DNA more accessible to the proteins that are responsible for activating the genes in that region. Other tags in other locations do the opposite, or attract other proteins with other specific functions." https://www.theguardian.com/science/occams-corner/2014/apr/25/epigenetics-beginners-guide-to-everything View in LinkedIn

MILK PROCESSING LOSS OF miRNA. "The concentrations of miRNAs in dairy products were considerably lower than in store-bought milk. We conclude that processing of milk by dairies and handling by consumers causes a significant loss of miRNAs." https://lnkd.in/eir_8rP View in LinkedIn

REGULATION OF REGULATION. "It is now known that epigenetic modifications control gene expression by modulating the access of regulatory complexes to the genome." https://lnkd.in/eQGP8zr View in LinkedIn