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PROTEIN BLUEPRINT. "DNA serves as a stable information storage medium and every protein which is needed by the cell is produced from this blueprint via an RNA intermediate code." https://lnkd.in/eJg7ubh View in LinkedIn

CELL CYCLE ORDER. "This is accomplished by delaying the entry into the next phase until the risk factors (such as DNA damage in G1/S/G2 phase, spindle abnormality prior to anaphase, etc.) are removed. Another important function of cell cycle checkpoint is to effectively trigger some processes (e.g. apoptosis, mitotic catastrophe, and senescence) to eliminate the severely damaged or high risk cells from the dividing pool." http://www.sciencedirect.com/science/article/pii/S1535610803000278 View in LinkedIn

DNA PACKAGING into chromosomes, the next step. Another brilliant animation. https://lnkd.in/efNVEqJ View in LinkedIn

CYCLE ORDERLINESS. "Because the cell division is conducted in an orderly manner, the progression of the cell cycle is highly coordinated. Premature entry of a cell into the next cell cycle phase would result in significant propensity for genomic alterations. Cell cycle checkpoints are built to ensure that progression from one phase to the next is under a condition of minimum risk of genomic alteration." http://www.sciencedirect.com/science/article/pii/S1535610803000278 View in LinkedIn

DNA REPLICATION ANIMATION. Complexity reduced to beauty. A picture animation is worth a thousand words. A must-see. Show your children. https://lnkd.in/ez8JfGr View in LinkedIn

THE GATEKEEPERS. "The majority of DNA synthesis performed in a human cell is replication of the six billion nucleotide nuclear genome. The bulk of this polymerization is likely to be catalyzed by DNA polymerases δ, DNA polymerase ε, or both." https://lnkd.in/euw7dRD View in LinkedIn

TWO LIFE STRATEGIES. "We have extensive mechanisms to proof-read our DNA and keep out errors. Viruses skip this and accumulate errors at a high rate. Some viral errors mean that they cannot complete their life cycle. These are called defective viruses." https://lnkd.in/eV3d7kz View in LinkedIn

CONSTANT INSTABILITY THREATS. "Throughout the cell cycle, the genome encounters various forms of spontaneous and induced DNA damages." https://lnkd.in/bam9PGn View in LinkedIn

HIGH FIDELITY VS DIVERSITY. Two opposing pressures in nature are, on the one hand, the need for high fidelity replication of the DNA in multicellular animals with slow reproductive rates. On the other hand is the profound drive in rapidly reproducing viruses for instance, for enormous genetic diversity and mutation to rapidly adapt to new niches. View in LinkedIn

ENDOGENOUS GENOME PROOFREADING. "Cells protect themselves from accidental genome change with proofreading and DNA damage repair systems; localized point mutations result from the action of specialized trans-lesion mutator DNA polymerases." https://lnkd.in/eNNF3BJ View in LinkedIn