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SECOND TYPE OF EDITING. "(ii) Co-opted adaptations of ribozymatic or ribozyme-like parts as remnants of former viral colonizers that now act as a great variety of regulatory elements in the present highly dynamic RNA world shortly after transcription out of stable DNA storage medium." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn

DEFINED BY CONTEXT. "The function of a protein is often tied to its interactions, and many proteins function as components of large multiprotein complexes. Multiprotein complexes also will connect to each other in a cell to carry out coordinated biological functions. Every cell has a network of protein interactions, where these connections within and between proteins and complexes yield insights into cellular states." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0913-4 View in LinkedIn

FIRST TYPE OF EDITING. "We can identify two complementary kinds of natural genome editing: (i) long lasting and stable inherited alterations of the cellular DNA genomes by persistent viral infections that alter genetic host identity." https://lnkd.in/eJg7ubh View in LinkedIn

FRAGMENT FROM NATURE features interactomes. The last two weekends focused on gene quantity and the immense protein space. Now we see how it all comes together as proteins form larger associations and interactions, synergistically adding to complexity and functional capability. This connects the genotype to the phenotype. And it all needs coordination on a vast scale. View in LinkedIn

VIRAL EDITOR'S PEN. "There are some indicators that viruses and viral-derived elements are the agents that edit the genome in host organisms, such as the non-lytic but persistent colonization of prokaryotes and eukaryotes by viral agents." https://lnkd.in/eJg7ubh View in LinkedIn

ALTERNATIVE SPLICING. "In complex organisms, especially in mammals, before the transcript is processed to the final mRNA for translation into protein, natural genetic engineering occurs which we call alternative splicing." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn

OUTSTANDING REVIEW on viral genome editing, and the source of a number of upcoming quotes. Worth a close read. https://lnkd.in/eJg7ubh View in LinkedIn

GENETIC TEXT EDITORS. "Three RNA assemblages are currently known to play vital roles in editing genetic text as a read-and-write medium." http://jmcb.oxfordjournals.org/content/early/2011/03/31/jmcb.mjr005.full View in LinkedIn

GENOME EDITING IS IMPORTANT. "There is growing evidence that natural genome-editing competences of viruses are essential for the evolution of the eukaryotic nucleus, the adaptive immune system and the placental mammals." https://lnkd.in/e-pJFM6 View in LinkedIn

PART OF THE WHOLE. "The function of a protein is often tied to its interactions, and many proteins function as components of large multiprotein complexes. Multiprotein complexes also will connect to each other in a cell to carry out coordinated biological functions. Every cell has a network of protein interactions, where these connections within and between proteins and complexes yield insights into cellular states." https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0913-4 View in LinkedIn