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DNA AS EMERGENT PROPERTY. "Thus the genetic code looks like an emergent property of self-organizing matter and information that underlies natural laws such as thermodynamics, kinetics, atomic structure and their binding forces." https://lnkd.in/eg6uePF View in LinkedIn

BRINKMANSHIP. "More detailed, error-prone RNAs are a resource for generating genetic diversity followed by selection out of cumulative series of error replications. If the error rate is too high, then genetic content gets lost, followed by quasi-species collapse." https://lnkd.in/eg6uePF View in LinkedIn

OLD ASSUMPTION. "For decades it was assumed that if the genetic code represents a context-free universal grammar determined exclusively by natural laws, copying events can form only identical copies of the wild type. If there is any change in such copies it is correct to term them as replication errors. Error replications (mutations) are a key element in explanatory models of the evolutionary origin of genetic diversity, being the ultimate resource for biological selection." https://lnkd.in/eg6uePF View in LinkedIn

TWO WAY STREET. "There is downward causation from the organism to the gene, not just as we assume, upward causation, from the gene to the organism. The reductionist agenda is incorrect. You are in the wrong box." (Professor Nobel on his book, the Music of Life). https://www.dpag.ox.ac.uk/team/denis-noble View in LinkedIn

ACTIVE GENOME EDITING AGENTS. "The reductionistic and mechanistic views on physico-chemical properties of the genetic code are no longer convincing as appropriate descriptions of the abundance of non-random genetic content operators which are active in natural genetic engineering and natural genome editing." https://lnkd.in/eg6uePF View in LinkedIn

USELESS WITHOUT AGENTS. "Genes do nothing on their own...if I take a gene and put it in a Petri dish with as many nutrients as you wish for 10,000 years, it will do absolutely nothing." (Professor Nobel on his book, the Music of Life). https://www.dpag.ox.ac.uk/team/denis-noble View in LinkedIn

ERROR VERSUS INTENTIONALITY. "The abundance of empirical data concerning non-random genetic change operators such as the variety of mobile genetic elements, persistent viruses and defectives do not fit with the dominant narrative of error replication events (mutations) as being the main driving forces creating genetic novelty and diversity." https://lnkd.in/eg6uePF View in LinkedIn

TWO WAY. "The same genome can give rise to very different phenotypes...transmission of information is not just one way...Lamarkism is not so obviously false." (Professor Nobel on his book, the Music of Life). https://www.dpag.ox.ac.uk/team/denis-noble View in LinkedIn

RISE OF RNA AGENTS. "Since Barbara McClintock’s far-reaching detection of mobile genetic elements, the RNA world hypothesis followed by the rise of RNA biology and the comeback of virology, we have a variety of terms for RNA agents that play essential roles in natural genetic engineering and natural genome editing." https://lnkd.in/eg6uePF View in LinkedIn

NEW INFO #2. "The central dogma of molecular biology “DNA-RNA-Protein everything else,” is obsolete nowadays; the reverse direction is also in common use." https://lnkd.in/eUYvi8e View in LinkedIn