linkedin post 2016-02-21 06:02:17

INTRINSIC PATHWAY. “The cell autonomous or intrinsic pathway is largely centered around and/or regulated by the mitochondria. The most widely studied form of intrinsic apoptosis is initiated by the stress-mediated release of cytochrome c from the mitochondria that results in the formation of the apoptosome. The apoptosome then activates initiator caspase, typically caspase 9, which leads to the activation of the executioner caspase 3. This leads to the same type of apoptotic response as observed for the extrinsic pathway.”

http://www.sciencedirect.com/science/article/pii/S0167488910002764

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