“CONTRARY to the conventional view that proteins evolve one amino acid at a time, we realized over 40 years ago that larger-scale changes play a major role. Whatever the exact molecular mechanism may be, duplication of an entire protein coding sequence can only occur by NGE, not by a succession of small mutations.” (NGE = Natural Genetic Engineering).
http://www.thethirdwayofevolution.com/people/view/james-a-shapiro