“THE REGULATORY HYPOTHESIS predicts that phenotypic evolution is, in most cases, associated with changes in gene expression. Unlike the more stringent cis-regulatory hypothesis championed by Carroll, the more general regulatory hypothesis makes no clear prediction about the molecular nature of the genetic changes underlying regulatory evolution (i.e. whether they are cis or trans), emphasizing only that regulation is key to developmental evolution.”
https://lnkd.in/dD4GcAS