HOTSPOT GENE CONVERSION. “One process recognized as a major evolutionary force re-shaping the genomic nucleotide landscape at recombination hotspots, as shown in humans, chimpanzees, mice, yeast, and metazoans, is GC-biased gene conversion (gBGC). In gBGC, the repair of heteroduplex tracts formed during meiotic recombination leads to the non-Mendelian segregation of alleles favoring GC over AT variants.”
https://lnkd.in/df6FZrB
linkedin post 2022-06-29 05:12:48
Nigel Fleming
September 21, 2022