TENTH CENTURY SMALLPOX VACCINES. “In 429 BCE, Greek historian Thucydides recorded that people who survived the smallpox epidemic in Athens were safe from re-infection. 900-1000 AD. The first precursor to a modern vaccination, however, occurred in China. The Chinese were the first to develop a primitive form of a vaccine around the 10th century, according to the NHS. Known as variolation or inoculation, the method was developed to prevent smallpox.”
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