Month: September 2022

HYPOTHESIS. "It remains largely unknown how the circadian clock connects to photoperiod-induced seasonal change in physiology and behavior in vertebrates. We hypothesized phase and amplitude plasticity in the oscillations of Per2, Cry1, Bmal1, and Clock genes with photoperiod-induced phenotypes in a seasonal species." http://www.fasebj.org/content/29/10/4248.full View in LinkedIn

KAPUT (CLOCK) mRNA. "Phase relationship in mRNA oscillations was altered between oscillator components in the circadian pacemaker system (retina, pineal, hypothalamus) as well as in the peripheral (liver, muscle) tissues. These results show for the first time altered waveforms of clock gene expressions in all tissues in parallel with behavioral shifts and suggest the involvement of circadian system in photoperiod induction of seasonal LHSs in a migratory species." (LHS = life history states). http://www.fasebj.org/content/29/10/4248.full View in LinkedIn

MIGRATORY GENE CANDIDATE. "We found a consistent association between a microsatellite polymorphism and migratory behaviour only at one candidate locus: the ADCYAP1 gene. This polymorphism explained about 2.6 per cent of the variation in migratory tendency among populations, and 2.7–3.5% of variation in migratory restlessness among individuals within two independent populations." http://rspb.royalsocietypublishing.org/content/early/2011/02/11/rspb.2010.2567 View in LinkedIn

NEUROPEPTIDE CANDIDATE. "The ADCYAP1 gene encodes the pituitary adenylate cyclase-activating polypeptide (PACAP), which is one of the most studied neuropeptides (more than 3000 papers deal directly with PACAP). The peptide and its receptors are widely distributed in the brain and in various peripheral organs." http://rspb.royalsocietypublishing.org/content/early/2011/02/11/rspb.2010.2567 View in LinkedIn

BEHAVIORAL AND PHYSIOLOGIC LINKS. "PACAP has a broad spectrum of biological functions with profound influence on physiology and behaviour. Most of the reported effects exerted by PACAP are indeed strongly linked to the physiological and behavioural shifts described for avian migration." http://rspb.royalsocietypublishing.org/content/early/2011/02/11/rspb.2010.2567 View in LinkedIn

CIRCADIAN LINKS. "PACAP has also been shown to directly influence clock gene expression and affect signalling pathways that integrate the molecular clock in the functionality of circadian rhythms in a dose- and phase-dependent manner." http://rspb.royalsocietypublishing.org/content/early/2011/02/11/rspb.2010.2567 View in LinkedIn

EXTERNAL ADMINISTRATION. "PACAP has also a strong modifying effect on the energy metabolism. Intracerebroventricularly administered PACAP appeared to stimulate catabolic effects on energy metabolism in chicken: it increased body temperature, metabolic rate and lipid utilization. Moreover, increased PACAP concentrations in the chicken brain inhibited feeding, which was later shown to be mediated by corticosterone release." http://rspb.royalsocietypublishing.org/content/early/2011/02/11/rspb.2010.2567 View in LinkedIn

LIKELY ROLE. "All these shifts in metabolism and feeding behaviour have been described as the characteristics of birds preparing for or performing long-distance migratory flights. Given the multiple pleiotropic functions of PACAP, ADCYAP1 has at least the potential to modify multiple physiological and behavioural changes during the migratory period." http://rspb.royalsocietypublishing.org/content/early/2011/02/11/rspb.2010.2567 View in LinkedIn

ROLE FOR CLOCK. "Many of these studies uncovered a regulatory role for Clock (e.g., migratory timing in Chinook and Pacific salmon; breeding phenology in blue tits and barn swallows; and migratory propensity in the Junco genus and barn swallows; timing of migration assessed via light-level geolocators." https://lnkd.in/dWFycUQ View in LinkedIn

NO CORRELATION. "Subsequent studies on different populations or taxa have failed to find similar associations (e.g., no correlation with latitudinal clines in bluethroats, barn swallows, Tachycineta swallows or three-spined stickleback, breeding phenology in great tits or barn swallows, or migratory propensity in blackcaps." https://lnkd.in/dWFycUQ View in LinkedIn