Month: September 2022

BILATERAL CROSSCHAT. "The host may also use chemical sensing to monitor microbial activity...a direct link between secreted bacterial products and chemosensory activation mechanisms for mucosal clearance." At the same time salivary and gingival antibodies play a key role in microbial colonization in the mouth. https://lnkd.in/egd9rZS View in LinkedIn

TASTE RECEPTORS AND ORAL HEALTH. "Specific alleles of the T2R38 bitter taste receptor have also been associated with a reduced risk for caries...it is tempting to suggest a mechanistic relationship between bitter taste and antimicrobial defense in the oral cavity." https://lnkd.in/egd9rZS View in LinkedIn

TASTE RECEPTOR DEFENDS LUNGS. "The human respiratory system is directly exposed to a continual stream of toxins and microbial pathogens. The oral bitter taste receptor, T2R38, which is key for avoiding toxic or poisonous foods, turns out to also be key in defending the human upper airway from microbial pathogens." https://lnkd.in/eEVGp7V View in LinkedIn

ENDOCRINE TASTE RECEPTORS. "The taste buds also serve as endocrine organs and secrete regulatory hormones in response to nutrient stimulation, including glucagon like peptide (GLP-1) and glucagon, among other endocrine peptides." These digestive hormones in turn signal organs like the pancreas to prepare to secrete insulin in response to the increase in blood glucose. http://www.sciencedirect.com/science/article/pii/S0960982213004181 View in LinkedIn

BIOME AND TASTE RECEPTORS. "Taste stimuli are typically released when food is chewed, dissolved in saliva and pre-digested by enzymes, such as amylase, lipase, and protease." However, given the abundant symbiotic microbiome, how much are they involved with activating our taste receptors by pre-metabolizing our food in the oral cavity? http://www.sciencedirect.com/science/article/pii/S0960982213004181 View in LinkedIn

TASTE RECEPTORS AND SATIETY. "Taste matters -- bypassing taste receptors boosts insulin and CCK satiety hormone response to food...a relative lack of oral stimulation, due to e.g., caloric beverage or other fast food consumption, can result in overeating by weakening satiety." https://lnkd.in/eET3vB2 View in LinkedIn

TASTE RECEPTORS IN THE GUT. "TAS1R and TAS2R-type receptors are expressed in the gustatory system, where they detect sweet- and bitter-tasting stimuli, respectively. These receptors are also expressed in subsets of cells within the mammalian gastrointestinal tract, where they moderate nutrient assimilation and endocrine responses." https://lnkd.in/ewWCUSe View in LinkedIn

TASTE RECEPTOR AND METABOLISM. "TAS2R haplotype is associated with altered glucose and insulin homeostasis...a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease." http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597743/ View in LinkedIn

ORAL MICROBIOME AND BLOOD-BRAIN BARRIER. "We propose for a subset of AD patients, aging favors the overgrowth of oral anaerobes established earlier in life provoking a pro-inflammatory innate response that weakens the BBB allowing bacteria to spread and quietly influence the pathogenesis of AD." http://www.researchgate.net/profile/Deborah_Shoemark/publication/264794791_The_Microbiome_and_Disease_Reviewing_the_Links_between_the_Oral_Microbiome_Aging_and_Alzheimer's_Disease/links/53fd9d340cf22f21c2f816ab.pdf View in LinkedIn

ORAL BIOME AND AGING. "Immunosenescence results in increased bacterial load as cell-mediated and humoral immune responses wane. The innate immune system gradually takes over; contributing to the rise in circulating proinflammatory cytokines such as TNF. Maintaining the integrity of the blood-brain barrier (BBB) against a backdrop of increasing bacterial load is important." http://www.researchgate.net/profile/Deborah_Shoemark/publication/264794791_The_Microbiome_and_Disease_Reviewing_the_Links_between_the_Oral_Microbiome_Aging_and_Alzheimer's_Disease/links/53fd9d340cf22f21c2f816ab.pdf View in LinkedIn