Month: September 2022

CHIRAL SWITCHES. "Between 2001 and 2011 the FDA approved 9 single enantiomer versions of racemic products. Eight of the drugs had racemic precursors available in the United States." https://lnkd.in/e_xecdi View in LinkedIn

OMEPRAZOLE (Prilosec for GI reflux) was an AstraZenica blockbuster drug. It is an unusual chiral molecule. When the patent ran out, AstraZenica launched Omeprazole (Nexium) which is the more potent S enantiomer. All about chirality and symmetry. https://lnkd.in/ehp6ekJ View in LinkedIn

NOT ALWAYS BETTER. "Optically pure pharmaceuticals may undergo racemization in vivo negating single enantiomer benefits or inducing unexpected effects...enantiomers may possess different carcinogenicity or teratogenicity." https://lnkd.in/ebgdD7x View in LinkedIn

THE $64,000 QUESTION. "Why are the molecules of life not ambidextrous? The interactions of light and magnetic fields might explain the way that life has a mysterious twist at its core." https://lnkd.in/eDJyJTn View in LinkedIn

CHIRALITY FROM OUTER SPACE. "A substantial fraction of the organic compounds on the early earth may have been derived from comet and meteorite impacts. The stable carbon isotope composition of individual amino acids in Murchison (meteorite) support an extraterrestrial origin -- rather than a terrestrial overprint of biological amino acids." https://lnkd.in/ekaC-VJ View in LinkedIn

CHIRAL MOLECULES AND METEORITES. "Irradiation of interstellar-like matter creates an organic residue that contains a noticeable asymmetry in the chiral amino acid alanine." https://lnkd.in/e_DRbaG View in LinkedIn

CHIRAL MOLECULES AND METEORITES. "Specifically, they found a 1.3% reduction...in the amount of left-handed alanine...is of the same order of magnitude as the asymmetric fraction of amino acids discovered in primitive meteorites." https://lnkd.in/e_DRbaG View in LinkedIn

CREATING CHIRALS. "It is possible to create "asymmetrical molecules of life" in space-like conditions from a mixture that does not contain any chiral substances...lends further weight to the idea that chiral asymmetry originates in space." https://lnkd.in/e_DRbaG View in LinkedIn

CREATING CHIRALS. "It is possible to create "asymmetrical molecules of life" in space-like conditions from a mixture that does not contain any chiral substances...lends further weight to the idea that chiral asymmetry originates in space." https://lnkd.in/e_DRbaG View in LinkedIn

D-AMINO ACIDS IN METEORITES. "Murchison contains common amino acids such as glycine, alanine and glutamic acid as well as unusual ones like isovaline and pseudoleucine. A complex mixture of alkanes was isolated as well, similar to that found in the Miller–Urey experiment." https://lnkd.in/e6T2vir View in LinkedIn