Year: 2022

CLOCKS AND CANCER. “Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CLOCK CUES. “The circadian clock sustains self-perpetuating oscillations with a 24-h periodicity and is simultaneously synchronized with external environmental cues such as light, temperature and food intake, the so-called ‘zeitgebers’, or time-givers, that maintain an organism’s proper timekeeping (Fig. 1).” https://lnkd.in/dG2eBWiK View in LinkedIn

DYSCIRCADIA. “Disruptions in biological rhythms result in numerous physiological disorders in organismal homeostasis, with consequences that have been linked to several pathologies, including cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

CARCINOGENIC SHIFT WORK. “Circadian disruption has been associated with increased incidence of specific cancers in various epidemiological studies, though the causes and factors linked with this disruption remain somewhat unclear. In 2007, the International Agency for Research on Cancer (IARC) listed “shift work leading to a disruption in circadian rhythm” as a probable human carcinogen, classified as Group 2A.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

SHIFT WORK RISK. “For example, according to the Nurses’ Health Study and case-controlled studies conducted with Norwegian nurses, women that worked night shifts for less than 30 years had a moderately increased risk for breast cancer, and risk was further increased upon working 30 or more years of rotating shift work (relative risk (RR) = 1.36).” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

DISRUPTION DURATION. “Similarly, reports suggest that the risk of prostate cancer is increased in night-shift workers, and this risk is augmented with a longer duration of shift work, particularly for high-grade cancers.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

OTHER FACTORS. “Moreover, exposure to light at night may not be the only risk factor influencing circadian disruption and tumorigenesis.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

LATE EATERS. “A prospective study of 41,398 day-working adults in the French NutriNet-Sante cohort identified that ‘late-eaters’ (those that exhibited eating episodes after 9:30 p.m.) have an increased risk of breast and prostate cancer, with hazard ratios (HR) of 1.48 and 2.20, respectively.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

GENETIC SUSCEPTIBILITY. “Early landmark studies have shown that mice carrying mutations in individual genes related to the circadian clock (mutation of period 2 (Per2m/m); heterozygous ablation of aryl hydrocarbon receptor nuclear translocator–like protein 1 (Arntl) (Bmal1+/–); and double-null cryptochrome 1 (Cry1) and Cry2 (Cry1/2–/–)) are more susceptible to lymphoma, and when irradiated, these mutant mice have increased rates of lymphoma and hepatocellular carcinoma.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn

GENETIC EFFECT. “Altogether these studies provide compelling support for the notion that genetic disruption of key components of the clock mechanism increases tumorigenesis, but it is still unclear whether there is any specificity for distinct types of cancer.” https://www.nature.com/articles/s41591-018-0271-8?fbclid=IwAR01C2Z4J5lxVYDLhxIb9dPb3fhNSZSxwimZvhHaJ4n3-nVPpkt2PNqoukk View in LinkedIn