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EUKARYOTE VIRAL CLASSIFICATION. “This assemblage of virus families is known as nucleocytoplasmic large DNA viruses (NCLDV), or more recently, the proposed order “Megavirales.”.” http://onlinelibrary.wiley.com/doi/10.1111/nyas.12728/full View in LinkedIn

EUKARYOTIC DNA VIRUSES. “By far the largest and most common group of DNA viruses in eukaryotes consists of seven families of large viruses (including giant mimiviruses and pandoraviruses, with genomes in the Mb range) that share a common viral ancestry, as indicated by the conservation of approximately 50 (inferred) ancestral genes.” https://lnkd.in/eU7uHHB View in LinkedIn

EUKARYOTIC VIRUSES. “Altogether, eukaryotes are hosts to 18 recognized families of dsDNA viruses that infect a broad spectrum of unicellular and multicellular organisms, and many unclassified viruses, spanning almost the entire range of viral genome sizes, from approximately 4 kb to almost 2.5 Mb.” https://lnkd.in/eU7uHHB View in LinkedIn

EUKARYOTIC VIRAL PARASITE . “Compared to RNA viruses and retroelements, ssDNA and dsDNA viruses and mobile elements are less diverse and less abundant in eukaryotes, although both of these classes of selfish elements have been found in most eukaryotes.” https://lnkd.in/eU7uHHB View in LinkedIn

PRISONER TRIALS. “Lady Montague had Charles Maitland inoculate her 4-year-old daughter in the presence of physicians of the royal court. Charles Maitland was then granted the royal license to perform a trial of variolation on six prisoners in Newgate on August 9, 1721. The prisoners were granted the king's favor if they submitted to this experiment.” https://lnkd.in/eQfnZZv View in LinkedIn

EUKARYOTIC HOSTS. “In stark contrast to bacteria and archaea, eukaryotes are hosts to numerous, enormously diverse RNA viruses, as well as retroelements and retro-viruses.” http://onlinelibrary.wiley.com/doi/10.1111/nyas.12728/full View in LinkedIn

FIRST WESTERN ADVOCATE. “In 1715, Montagu had gone through her own bout of smallpox, and had been disfigured as a result. After learning about inoculation during her time in Turkey, she was determined to protect her six-year-old son from the disease through inoculation.” The vaccination occurred on March 1718, followed also successfully with her four year old daughter. https://lnkd.in/ezcRH6N View in LinkedIn

PROKARYOTIC HOSTS. “In prokaryotes, the great majority of viruses have dsDNA genomes, mostly within the range of 10–100 kb. The second most abundant class includes small ssDNA viruses. Retroelements comprise a small minority (no retroviruses are known), whereas RNA viruses are rare.” http://onlinelibrary.wiley.com/doi/10.1111/nyas.12728/full View in LinkedIn

SMALLPOX VARIOLATION “may have developed independently in China and India, because different routes of inoculation, nasal and cutaneous respectively, were used in these countries. It was said to have been introduced into Egypt by the Mamelukes in the 13th century, and was known in North and western Africa, at least from the late 17th century.” https://lnkd.in/edjPjCH View in LinkedIn

GENETIC DIFFERENCES. “The viromes (i.e., the compendia of all viruses and virus-like elements) of prokaryotes (archaea and bacteria) and eukaryotes are dramatically different.” http://onlinelibrary.wiley.com/doi/10.1111/nyas.12728/full View in LinkedIn