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NEW DISCIPLINE. “A science of complex matter, of informed, self-organized, evolutive matter.” https://lnkd.in/dN969hA View in LinkedIn

UNSTABLE DIVERSITY. “When the assembly occurs only in a narrow range of conditions, the system is unstable and presents a singularity; it may also display a bifurcation or a switching point between different assemblies. On the other hand, sensitivity to perturbations, while limiting the operation range, introduces diversity and adaptability in the self-organization process.” https://lnkd.in/dN969hA View in LinkedIn

CHEMICAL EMERGENCE. “At each level of increasing complexity novel features emerge that do not exist at lower levels, which are deducible from but not reducible to those of lower levels.” https://lnkd.in/dN969hA View in LinkedIn

ADAPTIVE MATTER. “In the long-range perspective, the development of chemical science is toward complex systems, spanning the broadest outlook from divided to condensed matter then to organized and adaptive matter, on to living matter and thinking matter, up the ladder of complexity.” https://lnkd.in/dN969hA View in LinkedIn

EVOLUTIVE CHEMISTRY. “The combination of the features of supramolecular systems—information and programmability, dynamics and reversibility, constitution and diversity—leads toward the emergence of adaptive/evolutive chemistry. It is, by essence, of supramolecular nature because it is determined by interaction with an external entity. It may be constitutional and/or morphological (as occurs in “induced fit” for instance). Adaptive chemistry implies selection and growth under time reversibility.” https://lnkd.in/dN969hA View in LinkedIn

“SELF-ORGANIZATION BY SELECTION requires dynamic diversity (constitutional and/or morphological) on which to operate. This is made possible by the implementation of CDC responding to the pressure of either internal or external factors. Selection has an implicit information content. It is also truly a supramolecular process, because it occurs in relation to interactions with surroundings (which may be either the medium or a more or less distant part of a folded macromolecule).” https://lnkd.in/dN969hA View in LinkedIn

“SELF-ORGANIZATION BY DESIGN has been pursued with the goal to achieve full control over the output supramolecular entity by means of correctly instructed components, specific interaction algorithms, and (as much as possible) strict programming. Design is knowledge-based and has an explicit information content.” https://lnkd.in/dN969hA View in LinkedIn

MOLECULAR EVOLUTION. “Whereas preorganization relies entirely on design, supramolecular self-organization introduces in addition the possibility to let the system build up by selection.” https://lnkd.in/dN969hA View in LinkedIn

THE UNDERDETERMINATION PROBLEM. “This inference is complicated by the high variable to observation ratio of genomics, which causes the intrinsic and heavily underdetermined nature of the genomics/systems biology marriage. Experimental designs involving time courses and or perturbation can provide significantly more, but rarely enough, information on the underlying system structure. Computational biologists address this high underdetermination problem using strategies such as variable selection.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn

AN INFERRED STRUCTURE. “While the measurement of expression genome-wide is only the first step in deriving system-level knowledge, it presents analytical challenges to this day. The main reason is that genomic experimental techniques measure individual parts of the system in parallel but cannot directly measure the system structure, which needs to be inferred.” https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-8-S2-S1 View in LinkedIn