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INTRINSICALLY DISORDERED (ID) REGIONS. "Proteins containing ID regions tend to take a central role in protein interaction networks; specifically, they act as hubs, interacting with multiple different partners across time and space, allowing for the co-ordination of many cellular activities. Especially critical in determining this role is their ability to bind more than one partner using the same region." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

HUB VULNERABILITY. "This makes them robust to random node failure relative to a network whose degree distribution is random, but it also creates a vulnerability to the loss of only a few hubs. Importantly, PPI networks are highly dynamic, as their constituents are often short-lived and can be modified (e.g. phosphorylation) to shift interaction preferences." (PPI = protein-protein interactions). http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

PROTEIN-PROTEIN INTERACTION (PPI). "It appears that all available PPI networks display scale free topology; this topology is surprisingly pervasive, having been previously observed in social networks and the Internet. In scale-free networks, most of the nodes have a small number of interaction partners (degree), but a small subset, the hubs, have a very large number of partners." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

CONTEXTUAL MEANING. "It is becoming increasingly clear that only by studying proteins within the context of their interaction networks will a more complete understanding of complex cellular processes and their disease-causing malfunctions be achievable." https://lnkd.in/f3kymud View in LinkedIn

FRAGMENT FROM NATURE illustrates how molecular promiscuity in disordered regions of proteins yield unexpected plasticity and desirable traits, but also a susceptibility for diseases. We usually think of the genome as highly ordered, but protein products of genes can show considerable disorder, or viewed alternatively, structural flexibility that is less geometrically or electronically constrained. These present opportunities as well as potential problems. View in LinkedIn

HUB GROUPINGS. "Numerous studies have broken the hub proteins into two separate categories: those that form simultaneous stable complexes with their many interaction partners (party/multi-interface/stable hubs), and those that interact transiently with their partners at separate times (date/singlish-interface/transient hubs). Of these two hub types, only the transiently interacting hubs were found to be enriched in disorder." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

DISORDER CONCENTRATION. "Hubs have higher levels of disorder than non-hubs." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

CENTRALITY. "Proteins with intrinsically disordered segments seem to occupy a central position in the interactome." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

LITMUS TEST. "I’ve been working on writing novels computationally for well over 10 years now and I’m still trying it, although I believe that within the next two to three years I will have broken its back and will produce 100,000-word novels in half an hour or so, novels that I think most people would consider to be creative." https://www.theguardian.com/technology/2015/oct/10/can-robots-be-creative View in LinkedIn

DESIRABLE TRAIT. "The studies performed on hub proteins in protein-protein interaction networks reveal that proteins with intrinsically disordered regions take on roles in which promiscuity is a desired trait." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn