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COSTS. "However, the use of promiscuity does not come without a cost: a number of diseases that have been associated with intrinsically disordered-containing proteins seem to be caused by undesirable interactions occurring upon altered expression of the intrinsically disordered-containing protein." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

FUNCTION OF PROMISCUOUS ID SEGMENTS. "Their use in assembling dynamic, macromolecular structures, their role as interaction switches in regulation and signalling, and their role as recognition elements in the PQC (protein quality control) system." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

INTER- AND INTRADIGM-MODULARITY. "Patil et al., concluded that transient hubs are more likely to interact intermodularly, allowing communication between different modules (a module simply being a highly interconnected process, like the transcription initiation machinery), whereas the stable hubs are more likely to interact intramodularly, allowing for the formation of the modules." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

HUB GROUPINGS. "Numerous studies have broken the hub proteins into two separate categories: those that form simultaneous stable complexes with their many interaction partners (party/multi-interface/stable hubs), and those that interact transiently with their partners at separate times (date/singlish-interface/transient hubs). Of these two hub types, only the transiently interacting hubs were found to be enriched in disorder." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

DISORDER CONCENTRATION. "Hubs have higher levels of disorder than non-hubs." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

CENTRALITY. "Proteins with intrinsically disordered segments seem to occupy a central position in the interactome." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

LITMUS TEST. "I’ve been working on writing novels computationally for well over 10 years now and I’m still trying it, although I believe that within the next two to three years I will have broken its back and will produce 100,000-word novels in half an hour or so, novels that I think most people would consider to be creative." https://www.theguardian.com/technology/2015/oct/10/can-robots-be-creative View in LinkedIn

DESIRABLE TRAIT. "The studies performed on hub proteins in protein-protein interaction networks reveal that proteins with intrinsically disordered regions take on roles in which promiscuity is a desired trait." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn

FUNCTIONALITY OF PROMISCUOUS BINDING. "These regions allow for functionality such as engaging in the formation of dynamic heteromeric structures which can serve to increase local activity of an enzyme or store a collection of functionally related molecules for later use." http://www.biochemj.org/content/454/3/361?sa=X&ved=0CDkQ9QEwEWoVChMIzdjAo5n2xgIVovRyCh0HSAum View in LinkedIn