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DISTINCT. "Tissue-regulated alternative coding exons and flanking constitutive exons less often overlapped folded protein domains compared to general alternative exons." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

CONSERVED EXONS. "Interestingly, tissue-regulated exons associated with the highest rates of disordered amino acids also tended to be the most highly conserved. For example, 63% of the 101 most disordered human brain, skeletal, and or heart-differentially spliced exons are also alternatively spliced in mouse, whereas only 31% of the least disordered 81 exons differentially spliced in these tissues were detected as alternatively spliced exons." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

DISORDER AND INTERACTIONS. "We systematically investigate properties of tissue-regulated alternative exons. We find that proteins containing these coding exons tend to have more interactions in PPI networks. Moreover, these exons, together with the flanking constitutive exons, are enriched in sequences predicted to be highly disordered." (PPI = protein-protein interactions). http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

ALTERNATIVE EXONS. "In contrast, differentially regulated alternative exons have not been examined for common functional features. This is an important issue to address, since these exons are generally conserved and maintain frame. Moreover, because they comprise only 10%–30% of total alternative exons, they may possess important functional features that have been overlooked." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

DISORDERED SEQUENCES. "Since disordered regions are highly enriched in ligand binding surfaces and posttranslational modification, this suggests that AS may frequently modulate protein-protein and other ligand interactions." (AS = alternative splicing). http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

TERTIARY STRUCTURE. "Analysis of splicing and protein tertiary structure has suggested that alternative exons can have diverse effects on protein folding and function but are also found on the surfaces, within loops or in predicted disordered regions of proteins." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

EXON SUBSETS. "Specific subsets of alternative exons, or “exon networks,” display coordinated regulation between different cell types or conditions. Such exons are often evolutionarily conserved and enriched in genes with related functions, implying that they are involved in important processes or pathway-specific activities. To date, however, the functions of alternative exons within these networks have not been systematically investigated." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

FUNCTIONS NOT KNOWN. "Alternative splicing plays a key role in the expansion of proteomic and regulatory complexity, yet the functions of the vast majority of differentially spliced exons are not known." http://www.sciencedirect.com/science/article/pii/S1097276512004820 View in LinkedIn

BOTH DOMAINS. "While some studies have shown that alternative splicing has a general tendency to avoid protein domains and include disordered regions, other studies have shown that a vast majority of alternatively spliced isoforms could potentially cause significant alterations in regions of the protein structural core." http://www.sciencedirect.com/science/article/pii/S1097276512004844 View in LinkedIn