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CASCADE AND INTEGRATE. “As Boolean logic gates are widely used in electronic circuits to build digital devices, logic operations are encoded in gene regulatory networks that cells use to cascade and integrate multiple environmental and cellular signals and to respond accordingly.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

TOOLBOX. “This could make it possible to decipher complex living systems and produce reliable behaviour in organisms through diverse genetic circuit modules.” https://www.nature.com/articles/srep08090 View in LinkedIn

QED. “The results show that new genetic logic devices can be engineered predictably from novel native orthogonal biological control elements using quantitatively in-context characterized parts.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

BIOCIRCUITS. “The ultimate goal of synthetic biology is to connect biological logic gates together to execute complex biological tasks as in electrical circuits.” https://www.nature.com/articles/srep08090 View in LinkedIn

KIT BASED. “The circuits were assembled using a parts-based engineering approach of quantitative characterization, modelling, followed by construction and testing.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

GENETIC LOGIC GATES. “The emerging field of synthetic biology integrates multiple digital inputs into a digital output, with the construction of diverse genetic logic gates, including those that perform AND and NOT functions.” https://www.nature.com/articles/srep08090 View in LinkedIn

UNIVERSAL. “The AND gate is demonstrated to be modular by applying new regulated promoters to the inputs, and connecting the output to a NOT gate module to produce a combinatorial NAND gate.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

GENE GATE. “The device comprises two co-activating genes hrpR and hrpS controlled by separate promoter inputs, and a σ54-dependent hrpL promoter driving the output. The hrpL promoter is activated only when both genes are expressed, generating digital-like AND integration behaviour.” https://www.nature.com/articles/ncomms1516 View in LinkedIn

THE AND GATE. “Modular and orthogonal genetic logic gates are essential for building robust biologically based digital devices to customize cell signalling in synthetic biology. Here we constructed an orthogonal AND gate in Escherichia coli using a novel hetero-regulation module from Pseudomonas syringae.” https://lnkd.in/dsEUY4ZP View in LinkedIn

INTERACTIVE. “The whole data set can be easily queried and downloaded from the website. In addition, SynBioLGDB allows researchers to submit new logic gates.” https://www.nature.com/articles/srep08090 View in LinkedIn