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SO ENDS this fragment from nature on the remarkable inflammasome, and on the defense mechanism inflammation, which can sometimes be hijacked by pathogens, or go awry and cause diseases. Powerful remedies need stringent controls. Inflammation is at the root of many pathologies, and despite complex controls, can still cause self-damage. View in LinkedIn

ANTAGONIST DRUGS. "Elevated local or systemic IL-1β has been linked to a number of human hereditary or acquired diseases, and antagonists of IL-1β or its receptor are proving successful treatments for a number of these diseases. Clinical trials are currently assessing efficacy of Anakinra and next-generation IL-1β inhibitors for a wider range of diseases, including cryopyrin-associated periodic syndromes (CAPS), gout, and type II diabetes." http://www.sciencedirect.com/science/article/pii/S0092867410000759 View in LinkedIn

CHRONIC INFLAMMATORY DISEASES. "Phase I/Phase II clinical trials have been concluded or are still underway by Astra-Zeneca, Pfizer, Evotec, and GlaxoSmithKline to test safety and efficacy of drug-like P2X7R blockers in several chronic inflammatory diseases such as osteoarthritis, rheumatoid arthritis, chronic obstructive pulmonary disease, and CD." https://lnkd.in/eNNPn5D View in LinkedIn

CENTRAL PROCESSING UNIT. "All data accumulated to date have confirmed that the inflammasome is the CPU that integrates signals responsible for (1) the initiation and amplification of inflammation, (2) the stimulation of innate and adaptive immunity, and (3) the modulation of cell growth and differentiation. Thus it is no surprise that increasing attention is paid to the development of drugs targeting this organelle." https://lnkd.in/eNNPn5D View in LinkedIn

DRUG TARGETS. "The fact that the NLRP3 (NOD-, LRR- and pyrin domain-containing) inflammasome in particular is under the control of numerous regulatory mechanisms provides several opportunities for therapeutic intervention." https://lnkd.in/eSuQQy4 View in LinkedIn

INFECTION AND CHRONIC DISEASE. "Clinical and epidemiologic studies have suggested an association between infectious agents and chronic inflammatory disorders and cancer. We propose that a key aspect of pathogenesis is an aberrant epithelial barrier that can be instigated by microbial toxins, environmental insults, or the genetic predisposition of the host." http://www.sciencedirect.com/science/article/pii/S0092867406001917 View in LinkedIn

"THE INFLAMMATORY MICROENVIRONMENT is a fundamental factor determining tumor progression. Interleukin-1β and IL-18 are commonly overexpressed in many tumors, and their concentration within biologic fluids may offer prognostic indications." https://lnkd.in/eNNPn5D View in LinkedIn

PICTORIAL of inflammation-related diseases and the pathways of activation of inflammation. https://lnkd.in/ehvCn2w View in LinkedIn

"MICRO-RNAs are evolutionarily conserved small non-coding RNAs consisting of on average 22 nucleotides. They mediate post-transcriptional changes in gene expression usually through binding to the 3′ untranslated region (3′UTR) of target mRNAs with their seed region." https://lnkd.in/erkHGt5 View in LinkedIn

HUGE DISEASE ROLE. "It was initially thought that the inflammasomes participated only in pathogen recognition and in the pathogenesis of a few, rare, hereditary inflammatory disorders. On the contrary, it is now clear that they have a central role in the pathogenesis of basically all types of chronic inflammation, in metabolic diseases and cancer." https://lnkd.in/eNNPn5D View in LinkedIn