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mRNAS. "In most cases they act after being transcribed from the stable DNA storage medium into a pretranscriptional or transcriptional modus, with the advantage of being active prior to all translated proteins." https://lnkd.in/euyhznh View in LinkedIn

VIRAL DRIVERS "contradicts former concepts that focused on viruses in the framework of (i) escape theories, that is, viruses are intact or deformed genetic parasites that escaped from cellular life, or that viruses (ii) evolved from cellular ancestors or (iii) that they are not living beings because they cannot live without cellular life." https://lnkd.in/euyhznh View in LinkedIn

MICRO-RNA REGULATORS. "A wide variety of small RNAs regulate key cellular processes of replication as well as genetic arrangements, rearrangements, recombination and repair, and even inventions." https://lnkd.in/euyhznh View in LinkedIn

VIRAL DRIVERS OF LIFE. "Recent research in microbiology, based on comparative genomics and phylogenetic analyses, has demonstrated that life must be viewed from the perspective of the crucial role played by viruses." https://lnkd.in/euyhznh View in LinkedIn

WORKHORSE REGULATORS. "It is predicted that every metazoan cell type at each developmental stage has a distinct miRNA expression profile." Not just tissue-specific but temporally-specific also. https://lnkd.in/euyhznh View in LinkedIn

DNA AS HABITAT FOR VIRAL PARTS. "DNA is not only an information-storing archive but a life habitat for linguistically-competent RNA agents, most of them seemingly of viral or subviral descent." https://lnkd.in/euyhznh View in LinkedIn

MICRO-RNAs. "They originate during the transcriptional process, when the actual text building blocks are put together for a protein and when most of the non-protein-coding RNA is cut out and appears to be left over. This involves an incredible 97% of the genome’s transcriptional output." https://lnkd.in/eDswHmC View in LinkedIn

BROAD REMIT. "The whole range of mobile genetic agents that are competent to edit the genetic code/nucleic acid language not only edit, but also regulate key cellular processes of replication as well as transcription, translation, re-combination, repair, and even inventions via a wide variety of small RNAs." https://lnkd.in/euyhznh View in LinkedIn

VIRUS-FIRST THESIS. "If we consider the important role of the highly structured and ordered regulatory network of noncoding RNAs as not being randomly derived, one of the most favorable models with explanatory power is the virus-first thesis. This means that the evolution of the noncoding RNA world is the result of persistent viral life strategies." https://lnkd.in/euyhznh View in LinkedIn

CYCLE WINDOWS FOR REGULATORS. "In general, noncoding RNAs play important roles as intermediate products in the function and structure of the host genome, for example, in the reproductive cycle of host cells from the start to the end of the S-phase. Regulatory functions are restricted to specific phases of the cell cycle." https://lnkd.in/euyhznh View in LinkedIn