Month: September 2022

"THE DENTIN layer below the enamel has significantly higher fraction of organic material, up to 30-40%. The dominant organic constituent of tooth and other calcified and connective tissues is collagen." https://lnkd.in/evjaNwH View in LinkedIn

BITE-INDUCED CURRENTS in the mouth were hypothesized to cause postoperative pain with dental materials. Although small currents were measured in isolated mechanically strained dental materials, but the literature ended there. https://lnkd.in/eKPdRZH View in LinkedIn

MOUTH ELECTRICITY not from piezoelectricity, to be confused with the galvanic currents caused by different metal conductors used in dentistry. When a spoon touches a mercury filling you can experience an electric shock, with saliva as the electrolyte. The sensitivity of the body is well within these amounts of electricity generated. https://lnkd.in/eWtcUtS View in LinkedIn

FRAGMENT IN NATURE this weekend continues with the theme of the interaction of the Microbiome and the taste receptors, both in the mouth and through the gut, which are a key regulator of satiety, food choices, and health. View in LinkedIn

TASTE RECEPTORS exist in the mammalian gut. How they coordinate with taste receptors in the mouth is an active subject of investigation. "Oral sensing seems to mostly influence food discrimination and nutrient appetite, while post-oral chemosensors may relate to nutrient utilization and inhibition of appetite." https://lnkd.in/eDDXHEC View in LinkedIn

GUT CHANGES AND TASTE RECEPTORS. "Both short and long term changes in the luminal contents alter expression of bitter taste receptors." https://lnkd.in/e36SVG6 View in LinkedIn

PROLIFERATION MINUS DEATH = RESIDUAL LIFE. "Even though the cells of the taste bud undergo constant turnover, the structural homeostasis of the bud is maintained by balancing cell proliferation and cell death. Compared with nongustatory lingual epithelial cells, taste cells express higher levels of several inflammatory receptors and signaling proteins." https://lnkd.in/evfercC View in LinkedIn

TASTE BUD CYTOKINES. "While immune cells, such a T-cells and macrophages, are rarely found in taste buds, high levels of expression of some immune-responses-associated molecules are found in taste buds...a specific subset of taste cells selectively express high levels of the inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha)." https://lnkd.in/erYucpp View in LinkedIn

BACTERIA AND TASTE. "Infection and inflammation are thought to contribute to or exacerbate taste disorders." https://lnkd.in/eGn-ntk View in LinkedIn

BACTERIAL PRODUCTS AFFECT TASTE CELLS. "Inflammatory activators, such as lipopolysaccharides (LPS) from bacteria can affect taste progenitor cell regeneration, taste cell turnover, and recovery of taste nerve response after section and dietary sodium restriction." https://lnkd.in/erYucpp View in LinkedIn