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SURVIVAL MECHANISM. "Notably, other types of DNA lesions, such as abasic sites or nicks generated by DNA deaminase acting to convert cytosine to uracil (a substrate for uracil N-glycosylase), can restore meiotic recombination in mutants of the fission yeast Schizosaccharomyces pombe lacking Spo11 (rec12) without generating double strand breaks." https://lnkd.in/ebVhXPf View in LinkedIn

COMPETITIVE ADVANTAGE. "Such a model is supported by the finding that the meiotic defects of S. cerevisiae spo11 mutants can be in part suppressed by gamma irradiation, suggesting that random double strand breaks can suffice to enhance meiotic crossovers and increase spore viability and germination." http://cshperspectives.cshlp.org/content/6/3/a016154.full View in LinkedIn

HYPOTHESIS. "Perhaps the most interesting hypothesis for why replication occurs before meiotic recombination in meiosis I is that in the pre-Spo11 era, the sister-chromatid copies served as the source of double strand breaks. Double strand breaks are formed by replication of nicked DNA, in which the nicks might have been incurred by UV or gamma rays before Spo11, and double strand breaks (but not nicks) are potent stimulators of homologous recombination." https://lnkd.in/ebVhXPf View in LinkedIn

MEIOSIS INNOVATION (4) "Homolog synapsis and the persistence of sister-chromatid cohesion through meiosis I into meiosis II." http://cshperspectives.cshlp.org/content/6/3/a016154.full View in LinkedIn

MEIOSIS INNOVATION (3) "Crossovers that occur between homologs and not between sister chromatids." http://cshperspectives.cshlp.org/content/6/3/a016154.full View in LinkedIn

MEIOSIS INNOVATION (2) "DNA replication stimulated at meiosis I and inhibited at meiosis II." http://cshperspectives.cshlp.org/content/6/3/a016154.full View in LinkedIn

SELF RECOGNITION. "The invention of meiosis puts pressure on the development of mechanisms wherein haploid cells first recognize other haploid cells with the same chromosome complement, and then fuse with them selectively." https://lnkd.in/ebVhXPf View in LinkedIn

MEIOSIS INNOVATION (1) "Mechanisms to promote breaks that stimulate meiotic recombination frequencies to higher levels than mitotic recombination frequencies." https://lnkd.in/ebVhXPf View in LinkedIn

SPECIATION STARTS. "Indiscriminate cell–cell fusions, although they may have generated important novelties during early protoeukaryotic evolution, generate disparate chromosome complements that are toxic to a successful meiosis." https://lnkd.in/ebVhXPf View in LinkedIn

FOUR INNOVATIONS. "At a molecular genetic level, the evolution of meiosis would have entailed the following" four innovations.” http://cshperspectives.cshlp.org/content/6/3/a016154.full View in LinkedIn