linkedin post 2019-12-21 07:11:46

linkedin post 2019-12-21 07:11:46

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SMALL CHANGES, VAST EFFECTS. "Alternative splicing regulates the localization of proteins, their enzymatic properties and their interaction with ligands. In most cases, changes caused by individual splicing isoforms are small. However, cells typically coordinate numerous changes in ‘splicing programs’, which can have strong effects on cell proliferation, cell survival and properties of the nervous system." http://www.sciencedirect.com/science/article/pii/S0378111912009791 View in LinkedIn
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linkedin post 2019-12-21 07:10:43

linkedin post 2019-12-21 07:10:43

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REGULATORY KINGDOM. "Experimental analysis of these protein isoforms showed that alternative splicing regulates binding between proteins, between proteins and nucleic acids as well as between proteins and membranes." http://www.sciencedirect.com/science/article/pii/S0378111912009791 View in LinkedIn
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linkedin post 2019-12-21 07:09:36

linkedin post 2019-12-21 07:09:36

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ALTERNATIVE SPLICING IN PLANTS. "Epigenetic control of alternative splicing. Alternative splicing affects protein complexity and transcript levels and stability. Alternative splicing in the plant circadian clock. Alternative splicing diversity in ecotypes and polyploids." http://www.sciencedirect.com/science/article/pii/S1360138512001276 View in LinkedIn
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linkedin post 2019-12-21 07:08:27

linkedin post 2019-12-21 07:08:27

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PLANT SPLICING. "More than 60% of intron-containing genes undergo alternative splicing (AS) in plants. This number will increase when AS in different tissues, developmental stages, and environmental conditions are explored." http://www.sciencedirect.com/science/article/pii/S1360138512001276 View in LinkedIn
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linkedin post 2019-12-21 07:00:41

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“Alternative splicing of mRNA precursors enables one gene to produce multiple protein isoforms with differing functions. Under normal conditions, this mechanism is tightly regulated in order for the human genome to generate proteomic diversity sufficient for the functional requirements of complex tissues." http://cancerdiscovery.aacrjournals.org/content/3/11/1228.short View in LinkedIn
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linkedin post 2019-12-21 06:57:58

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GIANT AMPLIFIER. "The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has profound functional effects." http://www.sciencedirect.com/science/article/pii/S0378111912009791 View in LinkedIn
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linkedin post 2019-12-21 06:51:48

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FRAGMENT FROM NATURE continues from last weekend and concludes this weekend on the theme of alternative splicing in genetics. This mechanism amplifies the number of proteins that a limited number of genes can make, thus playing a key role in evolution, allowing proteins with novel functions to expand the phenotype of organisms. Once again, the ingenuity of this chance event questions intention in nature. View in LinkedIn
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linkedin post 2019-12-20 07:03:15

linkedin post 2019-12-20 07:03:15

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EXTRAORDINARY STORY. "Kennedy’s dreams: His electrodes wouldn’t simply be a tool for helping locked-in patients to communicate but would also be the engine of an enhanced and cybernetic future in which people live as minds in metal shells.” http://www.wired.com/2016/01/phil-kennedy-mind-control-computer/ View in LinkedIn
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