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STILL UNRESOLVED. “Although endogenous control of rhythmic growth was described in oaks more than a century ago, the mechanisms involved have not yet been elucidated.” http://jxb.oxfordjournals.org/content/66/22/7113.full View in LinkedIn

Graffiti. View in LinkedIn

THE STUBBORN ILLUSION. “People like us, who believe in physics, know that the distinction between past, present, and future is only a stubbornly persistent illusion.”" "Albert Einstein View in LinkedIn

INTERNAL CLOCK OF TREES. "Endogenous rhythmic growth in oak trees is regulated by internal clocks rather than resource availability. The results indicate that rhythmic growth involves dramatic oscillations in plant metabolism and gene regulation between below- and above-ground parts. Ectomycorrhizal symbiosis may play a previously unsuspected role in smoothing these oscillations without modifying the rhythmic growth pattern." https://lnkd.in/ds4PhA9 View in LinkedIn

CONTROL LOOPS. “The clock appears thus far to be considerably conserved with the rest of the plant kingdom. Thanks to molecular studies, and the use of circadian reporter systems, we know that the central oscillator consists of three interlocking auto-regulatory transcriptional feedback loops.” https://lnkd.in/dyrdvNg View in LinkedIn

KEY CLOCK GENES. “Core clock components are defined as genes with protein products that are essential for the generation and regulation of circadian rhythms. Ablation of any of the core clock genes, Clock or Bmal1, Per1 or Per2, or Cry1 or Cry2, disrupts circadian physiology.” https://lnkd.in/dH6Ha79 View in LinkedIn

DEEPLY INGRAINED. “The circadian system is involved in maintaining energy homeostasis. Approximately 10% of the mammalian transcriptome display circadian oscillations. Among the rhythmic genes identified, many have a specific role in coordinating nutrient metabolism. For example, glucose transporters and the glucagon receptor, as well as multiple enzymes involved in the metabolism of sugars and the biosynthesis of cholesterols, are rhythmically expressed.” https://lnkd.in/dH6Ha79 View in LinkedIn

CLOCK MECHANISM. “The circadian clock is driven by an autoregulatory feedback loop. CLOCK and BMAL1 form a heterodimer that induces expression of Per and Cry through E-box enhancers. PER and CRY proteins accumulate in the cytoplasm throughout the circadian day. CK GENES. “Upon reaching critical levels, PER and CRY form a complex that translocates back to the nucleus to associate with CLOCK and BMAL1 and repress their own transcription. This process takes approximately 24 hours to complete a full cycle.” https://lnkd.in/dH6Ha79 View in LinkedIn